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From early graph models to more recent native graph databases, the landscape of implementations has evolved to cover enterprise-ready requirements. Because of the interconnected nature of its data, the biomedical domain has been one of the early adopters of graph databases, enabling more natural representation models and better data integration workflows, exploration and analysis facilities. In this work, we survey the literature to explore the evolution, performance and how the most recent graph database solutions are applied in the biomedical domain, compiling a great variety of use cases. With this evidence, we conclude that the available graph database management systems are fit to support data-intensive, integrative applications, targeted at both basic research and exploratory tasks closer to the clinic.<\/jats:p>","DOI":"10.1093\/database\/baab026","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T11:08:14Z","timestamp":1619867294000},"source":"Crossref","is-referenced-by-count":47,"title":["An overview of graph databases and their applications in the biomedical domain"],"prefix":"10.1093","volume":"2021","author":[{"given":"Santiago","family":"Tim\u00f3n-Reina","sequence":"first","affiliation":[{"name":"Departamento de Inteligencia Artificial, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), C\/Juan del Rosal, 16 Ciudad Universitaria, Madrid 28040, Spain"}]},{"given":"Mariano","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Inteligencia Artificial, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), C\/Juan del Rosal, 16 Ciudad Universitaria, Madrid 28040, Spain"}]},{"given":"Rafael","family":"Mart\u00ednez-Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Departamento de Inteligencia Artificial, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), C\/Juan del Rosal, 16 Ciudad Universitaria, Madrid 28040, Spain"}]}],"member":"286","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"2021051812390287600_R1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-0619-4","volume-title":"Modern Graph Theory","author":"Bollob\u00e1s","year":"1998","edition":"1st"},{"key":"2021051812390287600_R2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4302-1573-8_3","volume-title":"SQL: Access to SQL Server","author":"Harkins","year":"2002"},{"key":"2021051812390287600_R3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1145\/362384.362685","article-title":"A relational model of data for large shared data banks","volume":"13","author":"Codd","year":"1970","journal-title":"Commun. 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