{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:30:35Z","timestamp":1779179435432,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":189,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Institute of Environmental and Operational Medicine","award":["BWS17J025, BWS17J031"],"award-info":[{"award-number":["BWS17J025, BWS17J031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Trained immunity is a newly emerging concept that defines the ability of the innate immune system to form immune memory and provide long-lasting protection against previously encountered antigens. Accumulating evidence reveals that trained immunity not only has broad benefits to host defense but is also harmful to the host in chronic inflammatory diseases. However, all trained immunity-related information is scattered in the literature and thus is difficult to access. Here, we describe Trained Immunity DataBase (TIDB), a comprehensive database that provides well-studied trained immunity-related genes from human, rat and mouse as well as the related literature evidence. Moreover, TIDB also provides three modules to analyze the function of the trained-immunity-related genes of interest, including Reactome pathway over-representation analysis, Gene Ontology enrichment analysis and protein\u2013protein interaction subnetwork reconstruction. We believe TIDB will help developing valuable strategies for vaccine design and immune-mediated disease therapy.<\/jats:p>\n               <jats:p>Database URL: http:\/\/www.ieom-tm.com\/tidb<\/jats:p>","DOI":"10.1093\/database\/baab041","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T11:08:40Z","timestamp":1624619320000},"source":"Crossref","is-referenced-by-count":12,"title":["TIDB: a comprehensive database of trained immunity"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-8506","authenticated-orcid":false,"given":"Yang","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, No.1 Dali Road, Heping District, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, No.1 Dali Road, Heping District, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, No.38 Life Science Park Road, Changping District, Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, No.1 Dali Road, Heping District, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, No.1 Dali Road, Heping District, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, No.38 Life Science Park Road, Changping District, Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, No.1 Dali Road, Heping District, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"2021071004504822300_R1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe"},{"key":"2021071004504822300_R2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. 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