{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:23:54Z","timestamp":1763810634717,"version":"3.41.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["693174"],"award-info":[{"award-number":["693174"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>EpiSurf is a Web application for selecting viral populations of interest and then analyzing how their amino acid changes are distributed along epitopes. Viral sequences are searched within ViruSurf, which stores curated metadata and amino acid changes imported from the most widely used deposition sources for viral databases (GenBank, COVID-19 Genomics UK (COG-UK) and Global initiative on sharing all influenza data (GISAID)). Epitopes are searched within the open source Immune Epitope Database or directly proposed by users by indicating their start and stop positions in the context of a given viral protein. Amino acid changes of selected populations are joined with epitopes of interest; a result table summarizes, for each epitope, statistics about the overlapping amino acid changes and about the sequences carrying such alterations. The results may also be inspected by the VirusViz Web application; epitope regions are highlighted within the given viral protein, and changes can be comparatively inspected. For sequences mutated within the epitope, we also offer a complete view of the distribution of amino acid changes, optionally grouped by the location, collection date or lineage. Thanks to these functionalities, EpiSurf supports the user-friendly testing of epitope conservancy within selected populations of interest, which can be of utmost relevance for designing vaccines, drugs or serological assays. EpiSurf is available at two endpoints.<\/jats:p>\n               <jats:p>Database URL: http:\/\/gmql.eu\/episurf\/ (for searching GenBank and COG-UK sequences) and http:\/\/gmql.eu\/episurf_gisaid\/ (for GISAID sequences).<\/jats:p>","DOI":"10.1093\/database\/baab059","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T19:13:25Z","timestamp":1631819605000},"source":"Crossref","is-referenced-by-count":13,"title":["EpiSurf: metadata-driven search server for analyzing amino acid changes within epitopes of SARS-CoV-2 and other viral species"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-5750","authenticated-orcid":false,"given":"Anna","family":"Bernasconi","sequence":"first","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-5493","authenticated-orcid":false,"given":"Luca","family":"Cilibrasi","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-5886","authenticated-orcid":false,"given":"Ruba","family":"Al Khalaf","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-8425","authenticated-orcid":false,"given":"Tommaso","family":"Alfonsi","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-2415","authenticated-orcid":false,"given":"Stefano","family":"Ceri","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-2851","authenticated-orcid":false,"given":"Pietro","family":"Pinoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4528-6586","authenticated-orcid":false,"given":"Arif","family":"Canakoglu","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio 34\/5, Milano 20133, Italy"}]}],"member":"286","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"2022031012260830900_R1","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz132","article-title":"GenoSurf: metadata driven semantic search system for integrated genomic datasets","volume":"2019","author":"Canakoglu","year":"2019","journal-title":"Database"},{"key":"2022031012260830900_R2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/978-3-030-62522-1_29","volume-title":"Conceptual Modeling","author":"Bernasconi","year":"2020"},{"key":"2022031012260830900_R3","doi-asserted-by":"crossref","first-page":"D817","DOI":"10.1093\/nar\/gkaa846","article-title":"ViruSurf: an integrated database to investigate viral sequences","volume":"49","author":"Canakoglu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022031012260830900_R4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab478","article-title":"VirusViz: comparative analysis and effective visualization of viral nucleotide and amino acid variants","volume":"49","author":"Bernasconi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022031012260830900_R5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-75018-3_18","article-title":"CoV2K: a knowledge base of SARS-CoV-2 variant impacts. 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