{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T11:09:47Z","timestamp":1768043387353,"version":"3.49.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070662, 61832019, 32030063"],"award-info":[{"award-number":["32070662, 61832019, 32030063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19430750600"],"award-info":[{"award-number":["19430750600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical and Engineering and Scientific Research at Shanghai Jiao Tong University","award":["YG2021ZD02"],"award-info":[{"award-number":["YG2021ZD02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The recent viral outbreaks and the current pandemic situation urges us to timely address any emerging viral infections by designing therapeutic strategies. Multi-omics and therapeutic data are of great interest to develop early remedial interventions. This work provides a therapeutic data platform (Mammarenavirus (MMV)-db) for pathogenic mammarenaviruses with potential catastrophic effects on human health around the world. The database integrates vaccinomics and RNA-based therapeutics data for seven human pathogenic MMVs associated with severe viral hemorrhagic fever and lethality in humans. Protein-specific cytotoxic T lymphocytes, B lymphocytes, helper T-cell and interferon-inducing epitopes were mapped using a cluster of immune-omics-based algorithms and tools for the seven human pathogenic viral species. Furthermore, the physiochemical and antigenic properties were also explored to guide protein-specific multi-epitope subunit vaccine for each species. Moreover, highly efficacious RNAs (small Interfering RNA (siRNA), microRNA and single guide RNA (sgRNA)) after extensive genome-based analysis with therapeutic relevance were explored. All the therapeutic RNAs were further classified and listed on the basis of predicted higher efficacy. The online platform (http:\/\/www.mmvdb.dqweilab-sjtu.com\/index.php) contains easily accessible data sets and vaccine designs with potential utility in further computational and experimental work. Conclusively, the current study provides a baseline data platform to secure better future therapeutic interventions against the hemorrhagic fever causing mammarenaviruses.<\/jats:p>\n               <jats:p>Database URL: http:\/\/www.mmvdb.dqweilab-sjtu.com\/index.php<\/jats:p>","DOI":"10.1093\/database\/baab063","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T18:37:13Z","timestamp":1634582233000},"source":"Crossref","is-referenced-by-count":14,"title":["MMV-db: vaccinomics and RNA-based therapeutics database for infectious hemorrhagic fever-causing mammarenaviruses"],"prefix":"10.1093","volume":"2021","author":[{"given":"Taimoor","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, P.R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-7602","authenticated-orcid":false,"given":"Abbas","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, P.R. China"}]},{"given":"Dong-Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, P.R. China"},{"name":"State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, P.R. China"},{"name":"Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong 518055, P.R China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"2021102215042166500_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-56029-3_1","article-title":"Molecular phylogeny of the arenaviruses","volume":"262","author":"Clegg","year":"2002","journal-title":"Arenaviruses I"},{"key":"2021102215042166500_R2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/viro.1996.0248","article-title":"The phylogeny of New World (Tacaribe complex) arenaviruses","volume":"219","author":"Bowen","year":"1996","journal-title":"Virology"},{"key":"2021102215042166500_R3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2008.05.014","article-title":"Genetic diversity between and within the arenavirus species indigenous to western Venezuela","volume":"378","author":"Fulhorst","year":"2008","journal-title":"Virology"},{"key":"2021102215042166500_R4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2460\/javma.2005.227.904","article-title":"The arenaviruses","volume":"227","author":"Jay","year":"2005","journal-title":"J. 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