{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T13:42:49Z","timestamp":1770644569987,"version":"3.49.0"},"reference-count":191,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Key Project for Applied Fundamental Research","award":["2018KZDXM076"],"award-info":[{"award-number":["2018KZDXM076"]}]},{"name":"Development Project of Jilin Province of China","award":["20200401083GX"],"award-info":[{"award-number":["20200401083GX"]}]},{"name":"Development Project of Jilin Province of China","award":["2020C003"],"award-info":[{"award-number":["2020C003"]}]},{"name":"Development Project of Jilin Province of China","award":["2020LY500L06"],"award-info":[{"award-number":["2020LY500L06"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62072212"],"award-info":[{"award-number":["62072212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Province Key Laboratory of Big Data Intelligent Computing","award":["20180622002JC"],"award-info":[{"award-number":["20180622002JC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Body fluid proteome has been intensively studied as a primary source for disease biomarker discovery. Using advanced proteomics technologies, early research success has resulted in increasingly accumulated proteins detected in different body fluids, among which many are promising biomarkers. However, despite a handful of small-scale and specific data resources, current research is clearly lacking effort compiling published body fluid proteins into a centralized and sustainable repository that can provide users with systematic analytic tools. In this study, we developed a new database of human body fluid proteome (HBFP) that focuses on experimentally validated proteome in 17 types of human body fluids. The current database archives 11\u2009827 unique proteins reported by 164 scientific publications, with a maximal false discovery rate of 0.01 on both the peptide and protein levels since 2001, and enables users to query, analyze and download protein entries with respect to each body fluid. Three unique features of this new system include the following: (i) the protein annotation page includes detailed abundance information based on relative qualitative measures of peptides reported in the original references, (ii) a new score is calculated on each reported protein to indicate the discovery confidence and (iii) HBFP catalogs 7354 proteins with at least two non-nested uniquely mapping peptides of nine amino acids according to the Human Proteome Project Data Interpretation Guidelines, while the remaining 4473 proteins have more than two unique peptides without given sequence information. As an important resource for human protein secretome, we anticipate that this new HBFP database can be a powerful tool that facilitates research in clinical proteomics and biomarker discovery.<\/jats:p>\n               <jats:p>Database URL: https:\/\/bmbl.bmi.osumc.edu\/HBFP\/<\/jats:p>","DOI":"10.1093\/database\/baab065","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T19:41:35Z","timestamp":1633030895000},"source":"Crossref","is-referenced-by-count":30,"title":["HBFP: a new repository for human body fluid proteome"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2808","authenticated-orcid":false,"given":"Dan","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, University of Nebraska-Lincoln, 122E Avery Hall, 1144 T St., Lincoln, NE 68588, USA"},{"name":"Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, 2699 Qianjin Street, Changchun 130012, China"},{"name":"Department of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, 2699 Qianjin Street, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-0708","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, 2699 Qianjin Street, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueteng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, 2699 Qianjin Street, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-8392","authenticated-orcid":false,"given":"Qin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine, The Ohio State University, 310G Lincoln tower, 1800 cannon drive, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-4821","authenticated-orcid":false,"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, 2699 Qianjin Street, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-6850","authenticated-orcid":false,"given":"Juan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Nebraska-Lincoln, 122E Avery Hall, 1144 T St., Lincoln, NE 68588, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"2021101304431641200_R1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1373\/clinchem.2009.126706","article-title":"The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serum","volume":"56","author":"Anderson","year":"2010","journal-title":"Clin. 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