{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:42:14Z","timestamp":1767339734319,"version":"3.41.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972239 and 91953123 to ZX.L., 31601067 to H.C."],"award-info":[{"award-number":["81972239 and 91953123 to ZX.L., 31601067 to H.C."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fostering Fund of Fundamental Research for Young Teachers of Zhengzhou University","award":["JC21343016 to H.C."],"award-info":[{"award-number":["JC21343016 to H.C."]}]},{"name":"Program for Guangdong Introducing Innovative and Entrepreneurial Teams","award":["2017ZT07S096 to ZX.L."],"award-info":[{"award-number":["2017ZT07S096 to ZX.L."]}]},{"name":"Guangdong Esophageal Cancer Institute Science and Technology Program","award":["M201911 to Z.-X.L."],"award-info":[{"award-number":["M201911 to Z.-X.L."]}]},{"DOI":"10.13039\/501100013111","name":"Tip-Top Scientific and Technical Innovative Youth Talents of Guangdong special support program","doi-asserted-by":"crossref","award":["2019TQ05Y351 to ZX.L."],"award-info":[{"award-number":["2019TQ05Y351 to ZX.L."]}],"id":[{"id":"10.13039\/501100013111","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To date, various studies have found that the occurrence of cancer may be related to viral infections. Therefore, it is important to explore the relationship between viruses and diseases. The International Agency for Research on Cancer has defined six types of viruses as Class 1 human carcinogens, including Epstein\u2013Barr virus, hepatitis C virus, hepatitis B virus, human T-cell lymphotropic virus, human herpesvirus 8 and human papillomavirus, while Merkel cell polyomavirus is classified as \u2018probably carcinogenic to humans\u2019 (Group 2A). Therefore, in-depth research on these viruses will help clarify their relationship with diseases, and substantial efforts have been made to sequence their genomes. However, there is no complete database documenting these cancer-associated viruses, and researchers are not able to easily access and retrieve the published genomes. In this study, we developed iCAV, a database that integrates the genomes of cancer-related viruses and the corresponding phenotypes. We collected a total of 18\u2009649 genome sequences from seven human disease-related viruses, and each virus was further classified by the associated disease, sample and country. iCAV is a comprehensive resource of cancer-associated viruses that provides browse and download functions for viral genomes.<\/jats:p><jats:p>Database URL: http:\/\/icav.omicsbio.info\/<\/jats:p>","DOI":"10.1093\/database\/baab079","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T13:31:22Z","timestamp":1638883882000},"source":"Crossref","is-referenced-by-count":3,"title":["iCAV: an integrative database of cancer-associated viruses"],"prefix":"10.1093","volume":"2021","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingou","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-0610","authenticated-orcid":false,"given":"Ze-Xian","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6684-317X","authenticated-orcid":false,"given":"Han","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"2022021504133936200_R1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.coviro.2018.09.003","article-title":"More than just oncogenes: mechanisms of tumorigenesis by human viruses","volume":"32","author":"Gaglia","year":"2018","journal-title":"Curr. 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