{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:48Z","timestamp":1772138208645,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province-Outstanding Youth Projec","award":["2019B151502059"],"award-info":[{"award-number":["2019B151502059"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871921"],"award-info":[{"award-number":["81871921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic & Applied Basic Research Programs of Guangdong province","award":["2018KZDXM033"],"award-info":[{"award-number":["2018KZDXM033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accessible chromatin refers to the active regions of a chromosome that are bound by many transcription factors (TFs). Changes in chromatin accessibility play a critical role in tumorigenesis. With the emergence of novel methods like Assay for Transposase-accessible Chromatin Sequencing, a sequencing method that maps chromatin-accessible regions (CARs) and enables the computational analysis of TF binding at chromatin-accessible sites, the regulatory landscape in cancer can be dissected. Herein, we developed a comprehensive cancer chromatin accessibility database named CATA, which aims to provide available resources of cancer CARs and to annotate their potential roles in the regulation of genes in a cancer type-specific manner. In this version, CATA stores 2\u2009991\u2009163 CARs from 23 cancer types, binding information of 1398 TFs within the CARs, and provides multiple annotations about these regions, including common single nucleotide polymorphisms (SNPs), risk SNPs, copy number variation, somatic mutations, motif changes, expression quantitative trait loci, methylation and CRISPR\/Cas9 target loci. Moreover, CATA supports cancer survival analysis of the CAR-associated genes and provides detailed clinical information of the tumor samples.<\/jats:p>\n                  <jats:p>Database URL: CATA is available at http:\/\/www.xiejjlab.bio\/cata\/.<\/jats:p>","DOI":"10.1093\/database\/baab085","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T07:43:45Z","timestamp":1640763825000},"source":"Crossref","is-referenced-by-count":1,"title":["CATA: a comprehensive chromatin accessibility database for cancer"],"prefix":"10.1093","volume":"2022","author":[{"given":"Jianyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Central Laboratory of Molecular Biology, Medical College of Jiaying University , 146 Huangtang Road, Meizhou 514031, China"},{"name":"Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, and Shandong Academy of Medical Sciences , 440 Jiyan Road, Jinan 250000, China"}]},{"given":"Yanshang","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory of Molecular Biology, Medical College of Jiaying University , 146 Huangtang Road, Meizhou 514031, China"},{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , 22 Xinling Road, Shantou 515041, China"}]},{"given":"Haotian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , 107 Yanjiang Xilu, Guangzhou 510000, China"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , 22 Xinling Road, Shantou 515041, China"}]},{"given":"Lingyu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , 22 Xinling Road, Shantou 515041, China"}]},{"given":"Taisong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , 22 Xinling Road, Shantou 515041, China"}]},{"given":"Zhengmin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Harbin Medical University , Daqing Campus, Daqing 163319, China"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Harbin Medical University , Daqing Campus, Daqing 163319, China"}]},{"given":"Bo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Central Laboratory of Molecular Biology, Medical College of Jiaying University , 146 Huangtang Road, Meizhou 514031, China"}]},{"given":"Qiuyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Harbin Medical University , Daqing Campus, Daqing 163319, China"}]},{"given":"Xuecang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Harbin Medical University , Daqing Campus, Daqing 163319, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-5076","authenticated-orcid":false,"given":"Jianjun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , 22 Xinling Road, Shantou 515041, China"}]}],"member":"286","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"2022063018060441000_R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1898","article-title":"The chromatin accessibility landscape of primary human cancers","volume":"362","author":"Corces","year":"2018","journal-title":"Science"},{"key":"2022063018060441000_R2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8935-7-33","article-title":"Chromatin accessibility: a window into the genome","volume":"7","author":"Tsompana","year":"2014","journal-title":"Epigenet. 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