{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:44:45Z","timestamp":1776044685416,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003350"],"award-info":[{"award-number":["82003350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073418"],"award-info":[{"award-number":["82073418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Organ fibrosis represents a vital health threat that substantially contributes to yearly mortality rates. While a considerable amount of research has been conducted on fibrosis, these reports have only focused on specific organs as affected within distinct disorders. Accordingly, results from such studies have been unable to provide a comprehensive understanding of the pathological processes involved. Here, we describe the development of FibROAD, an open-access database that integrates evidence from fibrosis-associated disorders as obtained from both the literature and multi-omics data. This resource will greatly assist both researchers and clinicians in the comprehension and treatment of this condition. FibROAD currently involves an assembly of 232 strong evidence-based fibrosis-related genes (FRGs) as garnered from 909 PubMed publications and contains lists of multi-omics data from\u2009&amp;gt;\u20094000 samples including RNA-seq, single-cell RNA-seq, miRNA-seq, ChIP-seq, ATAC-seq MeDIP-seq and MBD-seq as obtained from 17 different organs in 5 species. Results from integrative analyses as obtained using FibROAD have demonstrated that FRGs can be indicators for a wide range of organ fibrosis and reveal potential pro-fibrotic candidate genes for fibrosis research. In conclusion, FibROAD serves as a convenient platform where researchers can acquire integrated evidence and a more comprehensive understanding of fibrosis-related disorders.<\/jats:p>\n               <jats:p>Database URL \u00a0https:\/\/www.fibroad.org<\/jats:p>","DOI":"10.1093\/database\/baac015","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T12:07:57Z","timestamp":1646222877000},"source":"Crossref","is-referenced-by-count":10,"title":["FibROAD: a manually curated resource for multi-omics level evidence integration of fibrosis research"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-6495","authenticated-orcid":false,"given":"Yu-Zhe","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Fei","family":"Hu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei-Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Li","family":"Rong","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"},{"name":"Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, No. 1023-1063 Southern shatai Road, Baiyum, Guangzhou 510515, China"},{"name":"State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), No. 1023-1063 Southern shatai Road, Baiyum, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-7405","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"},{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, No. 1023-1063 Southern Shatai Road, Baiyum, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu, Guangzhou 5100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2022031210400306300_R1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol. 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