{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:33:49Z","timestamp":1781015629079,"version":"3.54.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"key research and development plan of Zhejiang Province","award":["2021C02039"],"award-info":[{"award-number":["2021C02039"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY20F020016"],"award-info":[{"award-number":["LY20F020016"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172369"],"award-info":[{"award-number":["62172369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human papillomavirus (HPV) can cause condyloma acuminatum and cervical cancer. Some mutations of these viruses are closely related to the persistent infection of cervical cancer and are ideal cancer vaccine targets. Several databases have been developed to collect HPV sequences, but no HPV mutation database has been published. This paper reports a Chinese HPV mutation database (HPVMD-C), which contains 149 HPV genotypes, 468 HPV mutations, 3409 protein sequences, 4727 domains and 236 epitopes. We analyzed the mutation distribution among HPV genotypes, domains and epitopes. We designed a visualization tool to display these mutations, domains and epitopes and provided more detailed information about the disease, region and related literature. We also proposed an HPV genotype prediction tool, which can predict HPV carcinogenic or non-carcinogenic risk genotypes. We expect that HPVMD-C will complement the existing database and provide valuable resources for HPV vaccine research and cervical cancer treatment. HPVMD-C is freely available at<\/jats:p>\n               <jats:p>Database URL: http:\/\/bioinfo.zstu.edu.cn\/hpv.<\/jats:p>","DOI":"10.1093\/database\/baac018","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T12:06:31Z","timestamp":1646568391000},"source":"Crossref","is-referenced-by-count":36,"title":["HPVMD-C: a disease-based mutation database of human papillomavirus in China"],"prefix":"10.1093","volume":"2022","author":[{"given":"Zhenyu","family":"Yang","sequence":"first","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yi","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Sciences, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-6115","authenticated-orcid":false,"given":"Michael Q","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA"},{"name":"Division of Bioinformatics, Center for Synthetic and Systems Biology, TNLIST, Tsinghua University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-6511","authenticated-orcid":false,"given":"Qi","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"2022032913260957000_R1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1586\/14789450.3.1.21","article-title":"Role of proteomics in translational research in cervical cancer","volume":"3","author":"Yim","year":"2006","journal-title":"Expert Rev Proteomics"},{"key":"2022032913260957000_R2","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","article-title":"Global burden of human papillomavirus and related diseases","volume":"30","author":"Forman","year":"2012","journal-title":"Vaccine"},{"key":"2022032913260957000_R3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/jnci\/86.5.392-a","article-title":"Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia","volume":"86","author":"Schiffman","year":"1994","journal-title":"J. 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