{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:57:51Z","timestamp":1768431471787,"version":"3.49.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":185,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102646"],"award-info":[{"award-number":["82102646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA) is the most common form of arthritis in the adult population and is a leading cause of disability. OA-related genetic loci may play an important role in clinical diagnosis and disease progression. With the rapid development of diverse technologies and omics methods, many OA-related public data sets have been accumulated. Here, we retrieved a diverse set of omics experimental results from 159 publications, including genome-wide association study, differentially expressed genes and differential methylation regions, and 2405 classified OA-related gene markers. Meanwhile, based on recent single-cell RNA-seq data from different joints, 5459 cell-type gene markers of joints were collected. The information has been integrated into an online database named OAomics and molecular biomarkers (OAOB). The database (http:\/\/ibi.zju.edu.cn\/oaobdb\/) provides a web server for OA marker genes, omics features and so on. To our knowledge, this is the first database of molecular biomarkers for OA.<\/jats:p>","DOI":"10.1093\/database\/baac052","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:26:49Z","timestamp":1657024009000},"source":"Crossref","is-referenced-by-count":13,"title":["Multi-omics molecular biomarkers and database of osteoarthritis"],"prefix":"10.1093","volume":"2022","author":[{"given":"Jianhua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , 3 East Qingchun Road, Hangzhou, Zhejiang 310016, China"}]},{"given":"Xiaotian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , 3 East Qingchun Road, Hangzhou, Zhejiang 310016, China"}]},{"given":"Qinjie","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Zhejiang University , Hangzhou, Zhejiang 310058, China"}]},{"given":"Lingjuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Zhejiang University , Hangzhou, Zhejiang 310058, China"}]},{"given":"Yuwen","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Zhejiang University , Hangzhou, Zhejiang 310058, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-1523","authenticated-orcid":false,"given":"Xiaoxu","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Zhejiang University , Hangzhou, Zhejiang 310058, China"}]},{"given":"Michael P","family":"Timko","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Virginia, and Department of Public Health Sciences, UVA School of Medicine , Charlottesville, VA 22904, USA"}]},{"given":"Longjiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , 3 East Qingchun Road, Hangzhou, Zhejiang 310016, China"},{"name":"Institute of Bioinformatics, Zhejiang University , Hangzhou, Zhejiang 310058, China"}]}],"member":"286","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"2022070512263880400_R1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthr. 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Rheumatol."},{"key":"2022070512263880400_R5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41584-020-0407-3","article-title":"Interplay between genetics and epigenetics in osteoarthritis","volume":"16","author":"Rice","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"2022070512263880400_R6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2010.08.019","article-title":"Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis","volume":"19","author":"Kraus","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"2022070512263880400_R7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.joca.2020.11.003","article-title":"Osteoarthritis year in review: genetics, genomics, epigenetics","volume":"29","author":"Ratneswaran","year":"2021","journal-title":"Osteoarthr. 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