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Specifically, previous work has demonstrated that structural features of tissue and drug-treated cell line samples can be used to predict tissue type and characterize drug relationships, respectively. We have developed structural signatures, a web server for annotating and analyzing protein features from gene sets that are often found in transcriptomic and proteomic data. This platform provides access to a structural feature database derived from normal and disease human tissue samples. We show how analysis using this database can shed light on the relationship between states of single-cell RNA-sequencing lung cancer samples. These various structural feature signatures can be visualized on the server itself or downloaded for additional analysis. The structural signatures server tool is freely available at https:\/\/structural-server.kinametrix.com\/.<\/jats:p>","DOI":"10.1093\/database\/baac053","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T17:24:15Z","timestamp":1658856255000},"source":"Crossref","is-referenced-by-count":3,"title":["Structural signatures: a web server for exploring a database of and generating protein structural features from human cell lines and tissues"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-4056","authenticated-orcid":false,"given":"Nicole","family":"Zatorski","sequence":"first","affiliation":[{"name":"Department of Pharmacological Sciences, Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1677 New York, NY 10029, USA"}]},{"given":"David","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1677 New York, NY 10029, USA"}]},{"given":"Rayees","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1677 New York, NY 10029, USA"}]},{"given":"Ravi","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1677 New York, NY 10029, USA"},{"name":"Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1215 New York, NY 10029, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-7814","authenticated-orcid":false,"given":"Avner","family":"Schlessinger","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Institute for Systems Biomedicine Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1677 New York, NY 10029, USA"}]}],"member":"286","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"2022072614505577400_R1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/464670a","article-title":"Human genome at ten: the sequence explosion","volume":"464","year":"2010","journal-title":"Nature"},{"key":"2022072614505577400_R2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1586\/14789450.1.2.239","article-title":"Protein interaction networks","volume":"1","author":"Pellegrini","year":"2004","journal-title":"Expert Rev. 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