{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:25:12Z","timestamp":1762341912217,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":229,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Scientific and Technological Innovation Act Program of Science and Technology Commission of Shanghai Municipality","award":["18411950900"],"award-info":[{"award-number":["18411950900"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772040"],"award-info":[{"award-number":["81772040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772107"],"award-info":[{"award-number":["81772107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Clinical Research Project of Shanghai Hospital Development Center","award":["SHDC2020CR1028B"],"award-info":[{"award-number":["SHDC2020CR1028B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Sepsis, one of the major challenges in the intensive care unit, is characterized by complex host immune status. Improved understandings of the phenotypic changes of immune cells during sepsis and the driving molecular mechanisms are critical to the elucidation of sepsis pathogenesis. Single-cell RNA sequencing (scRNA-seq), which interprets transcriptome at a single-cell resolution, serves as a useful tool to uncover disease-related gene expression signatures of different cell populations in various diseases. It has also been applied to studies on sepsis immunopathological mechanisms. Due to the fact that most sepsis-related studies utilizing scRNA-seq have very small sample sizes and there is a lack of an scRNA-seq database for sepsis, we developed Sepsis Single-cell Whole Gene Expression Database Website (SC2sepsis) (http:\/\/www.rjh-sc2sepsis.com\/), integrating scRNA-seq datasets of human peripheral blood mononuclear cells from 45 septic patients and 26 healthy controls, with a total amount of 232\u2009226 cells. SC2sepsis is a comprehensive resource database with two major features: (i) retrieval of 1988 differentially expressed genes between pathological and healthy conditions and (ii) automatic cell-type annotation, which is expected to facilitate researchers to gain more insights into the immune dysregulation of sepsis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Database URL<\/jats:title>\n                  <jats:p>http:\/\/www.rjh-sc2sepsis.com\/<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/database\/baac061","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T12:07:12Z","timestamp":1660824432000},"source":"Crossref","is-referenced-by-count":4,"title":["SC2sepsis: sepsis single-cell whole gene expression database"],"prefix":"10.1093","volume":"2022","author":[{"given":"Yinjiaozhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"given":"Ruoming","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"given":"Zhaojun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"given":"Erzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-5125","authenticated-orcid":false,"given":"Hongping","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , No.197 Ruijin Er Road, Shanghai CN 200025, China"}]}],"member":"286","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2022081812070778900_R1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2022081812070778900_R2","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009\u20132014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"key":"2022081812070778900_R3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA"},{"key":"2022081812070778900_R4","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"JAMA"},{"key":"2022081812070778900_R5","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1164\/rccm.201403-0471OC","article-title":"Increased 1-year healthcare use in survivors of severe sepsis","volume":"190","author":"Prescott","year":"2014","journal-title":"Am. 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