{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:39:38Z","timestamp":1761824378258,"version":"3.41.2"},"reference-count":78,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":224,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Wenzhou-Kean University Student Partnering with Faculty (SpF) research program","award":["WKU201920009, SpF2021002 and SpS2021029"],"award-info":[{"award-number":["WKU201920009, SpF2021002 and SpS2021029"]}]},{"name":"Zhejiang Bioinformatics International Science and Technology Cooperation Center","award":["WB20210429000008"],"award-info":[{"award-number":["WB20210429000008"]}]},{"name":"Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics","award":["WB20211227000125"],"award-info":[{"award-number":["WB20211227000125"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Drug resistance remains a global threat, and the rising trend of consuming probiotic-containing foods, many of which harbor antibiotic resistant determinants, has raised serious health concerns. Currently, the lack of accessibility to location-, drug- and species-specific information of drug-resistant probiotics has hampered efforts to combat the global spread of drug resistance. Here, we describe the development of ProbResist, which is a manually curated online database that catalogs reports of probiotic bacteria that have been experimentally proven to be resistant to antibiotics. ProbResist allows users to search for information of drug resistance in probiotics by querying with the names of the bacteria, antibiotic or location. Retrieved results are presented in a downloadable table format containing the names of the antibiotic, probiotic species, resistant determinants, region where the study was conducted and digital article identifiers (PubMed Identifier and Digital Object Identifier) hyperlinked to the original sources. The webserver also presents a simple analysis of information stored in the database. Given the increasing reports of drug-resistant probiotics, an exclusive database is necessary to catalog them in one platform. It will enable medical practitioners and experts involved in policy making to access this information quickly and conveniently, thus contributing toward the broader goal of combating drug resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Database URL<\/jats:title>\n                  <jats:p>https:\/\/probresist.com.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/database\/baac064","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T12:46:49Z","timestamp":1660394809000},"source":"Crossref","is-referenced-by-count":7,"title":["ProbResist: a database for drug-resistant probiotic bacteria"],"prefix":"10.1093","volume":"2022","author":[{"given":"Wanying","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Computer Science, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemn Barzan","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Computer Science, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computer Science, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department 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and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics , Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Zhejiang Bioinformatics International Science and Technology Cooperation Center , Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechen","family":"Tian","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics , Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Zhejiang Bioinformatics International Science and Technology Cooperation Center , Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Yang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics , Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Zhejiang Bioinformatics International Science and Technology Cooperation Center , Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-5845","authenticated-orcid":false,"given":"Aloysius","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics , Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Zhejiang Bioinformatics International Science and Technology Cooperation Center , Ouhai, Wenzhou, Zhejiang 325060, China"},{"name":"Department of Computer Science, College of Science and Technology, Wenzhou-Kean University , 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"2022081312463842500_R1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2013.00052","article-title":"Recycling metchnikoff: probiotics, the intestinal microbiome and the quest for long life","volume":"1","author":"Mackowiak","year":"2013","journal-title":"Front. 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