{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:30:50Z","timestamp":1773466250669,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Cancer biomarkers are measurable indicators that play vital roles in clinical applications. Biomarkers in body fluids have gained considerable attention since the development of liquid biopsy, and their data volume is rapidly increasing. Nevertheless, current research lacks the compilation of published cancer body fluid biomarkers into a centralized and sustainable repository for researchers and clinicians, despite a handful of small-scale and specific data resources. To fulfill this purpose, we developed liquid biomarker (LiqBioer) containing 6231 manually curated records from 3447 studies, covering 3056 biomarkers and 74 types of cancer in 22 tissues. LiqBioer allows users to browse and download comprehensive information on body liquid biomarkers, including cancer types, source studies and clinical usage. As a comprehensive resource for body fluid biomarkers of cancer, LiqBioer is a powerful tool for researchers and clinicians to query and retrieve biomarkers in liquid biopsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Database URL<\/jats:title>\n                  <jats:p>http:\/\/www.medsysbio.org:8080\/LiqBioer<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/database\/baac077","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T14:28:29Z","timestamp":1662128909000},"source":"Crossref","is-referenced-by-count":5,"title":["LiqBioer: a manually curated database of cancer biomarkers in body fluid"],"prefix":"10.1093","volume":"2022","author":[{"given":"Yiding","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin 150081, China"}]},{"given":"Lu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin 150081, China"}]},{"given":"Guangjue","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin 150081, China"}]},{"given":"Zhangxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Sino-Russian Medical Research Centre, The Institute of Chronic Disease, The First Affiliated Hospital, Jinan University , Guangzhou, Guangdong 510630, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-4126","authenticated-orcid":false,"given":"Yunyan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin 150081, China"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Harbin Medical University , 157 Baojian Road, Nangang District, Harbin 150081, China"}]}],"member":"286","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"2022090214280838600_R1","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1111\/epi.13460","article-title":"WONOEP appraisal: molecular and cellular biomarkers for epilepsy","volume":"57","author":"Walker","year":"2016","journal-title":"Epilepsia"},{"key":"2022090214280838600_R2","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1158\/2159-8290.CD-20-1311","article-title":"Liquid biopsy: from discovery to clinical application","volume":"11","author":"Alix-Panabieres","year":"2021","journal-title":"Cancer Discov."},{"key":"2022090214280838600_R3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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