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However, despite the rapidly growing body of data on regulatory interactions in several eukaryotes, no databases exist to provide curated high-quality information on transcription factor\u2013target gene interactions for multiple species. Here, we address this gap by introducing the TFLink gateway, which uniquely provides experimentally explored and highly accurate information on transcription factor\u2013target gene interactions (\u223c12 million), nucleotide sequences and genomic locations of transcription factor binding sites (\u223c9 million) for human and six model organisms: mouse, rat, zebrafish, fruit fly, worm and yeast by integrating 10 resources. TFLink provides user-friendly access to data on transcription factor\u2013target gene interactions, interactive network visualizations and transcription factor binding sites, with cross-links to several other databases. Besides containing accurate information on transcription factors, with a clear labelling of the type\/volume of the experiments (small-scale or high-throughput), the source database and the original publications, TFLink also provides a wealth of standardized regulatory data available for download in multiple formats. The database offers easy access to high-quality data for wet-lab researchers, supplies data for gene set enrichment analyses and facilitates systems biology and comparative gene regulation studies.<\/jats:p>\n               <jats:p>Database URL https:\/\/tflink.net\/<\/jats:p>","DOI":"10.1093\/database\/baac083","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T16:09:15Z","timestamp":1663344555000},"source":"Crossref","is-referenced-by-count":151,"title":["TFLink: an integrated gateway to access transcription factor\u2013target gene interactions for multiple species"],"prefix":"10.1093","volume":"2022","author":[{"given":"Orsolya","family":"Liska","sequence":"first","affiliation":[{"name":"HCEMM-BRC Metabolic Systems Biology Research Group , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"},{"name":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, E\u00f6tv\u00f6s Lor\u00e1nd Research Network (ELKH) , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"},{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , P\u00e1zm\u00e1ny P. stny. 1\/C, Budapest 1117, Hungary"},{"name":"Doctoral School of Biology, University of Szeged , K\u00f6z\u00e9p fasor 52, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Boh\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , P\u00e1zm\u00e1ny P. stny. 1\/C, Budapest 1117, Hungary"},{"name":"Earlham Institute , Colney Ln, Norwich NR4 7UZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Hidas","sequence":"additional","affiliation":[{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , P\u00e1zm\u00e1ny P. stny. 1\/C, Budapest 1117, Hungary"},{"name":"Institute of Aquatic Ecology, Centre for Ecological Research, E\u00f6tv\u00f6s Lor\u00e1nd Research Network (ELKH) , Karolina \u00fat 29, Budapest 1113, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Korcsm\u00e1ros","sequence":"additional","affiliation":[{"name":"Earlham Institute , Colney Ln, Norwich NR4 7UZ, UK"},{"name":"Quadram Institute Bioscience, Norwich Research Park , Norwich NR4 7UQ, UK"},{"name":"Faculty of Medicine, Imperial College London, South Kensington Campus , London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Papp","sequence":"additional","affiliation":[{"name":"HCEMM-BRC Metabolic Systems Biology Research Group , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"},{"name":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, E\u00f6tv\u00f6s Lor\u00e1nd Research Network (ELKH) , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , P\u00e1zm\u00e1ny P. stny. 1\/C, Budapest 1117, Hungary"},{"name":"Earlham Institute , Colney Ln, Norwich NR4 7UZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-1067","authenticated-orcid":false,"given":"Eszter","family":"Ari","sequence":"additional","affiliation":[{"name":"HCEMM-BRC Metabolic Systems Biology Research Group , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"},{"name":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, E\u00f6tv\u00f6s Lor\u00e1nd Research Network (ELKH) , Temesv\u00e1ri krt. 62, Szeged 6726, Hungary"},{"name":"Department of Genetics, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , P\u00e1zm\u00e1ny P. stny. 1\/C, Budapest 1117, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"2022091616074434600_R1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrg1990","article-title":"The evolution of gene regulation by transcription factors and microRNAs","volume":"8","author":"Chen","year":"2007","journal-title":"Nat. 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