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It is difficult, however, to assemble a useful compendium of these biological properties if they are derived from experimental measurements performed at different sites under different experimental conditions. The Coronavirus Immunotherapeutic Consortium (COVIC) circumvents these issues by experimentally testing blinded antibodies side by side for several functional activities. To collect these data in a consistent fashion and make it publicly available, we established the COVIC database (COVIC-DB, https:\/\/covicdb.lji.org\/). This database enables systematic analysis and interpretation of this large-scale dataset by providing a comprehensive view of various features such as affinity, neutralization, in vivo protection and effector functions for each antibody. Interactive graphs enable direct comparisons of antibodies based on select functional properties. We demonstrate how the COVIC-DB can be utilized to examine relationships among antibody features, thereby guiding the design of therapeutic antibody cocktails.<\/jats:p>\n               <jats:p>Database URL \u00a0https:\/\/covicdb.lji.org\/<\/jats:p>","DOI":"10.1093\/database\/baac112","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T15:43:19Z","timestamp":1676043799000},"source":"Crossref","is-referenced-by-count":11,"title":["Coronavirus Immunotherapeutic Consortium Database"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-3944","authenticated-orcid":false,"given":"Jarjapu","family":"Mahita","sequence":"first","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , 9420 Athena Circle, La Jolla, CA 92037, USA"}]},{"given":"Brendan","family":"Ha","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La 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USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-9179","authenticated-orcid":false,"given":"S Moses","family":"Dennison","sequence":"additional","affiliation":[{"name":"Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute , Duke University, Durham, NC 27701, USA"}]},{"given":"Kan","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute , Duke University, Durham, NC 27701, USA"}]},{"given":"Natalia","family":"Kuzmina","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd , Galveston, TX 77555-0609, USA"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston , 301 University Blvd, Galveston, TX 77555-1019, 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Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive , 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA"}]},{"given":"Mary","family":"Osei-Twum","sequence":"additional","affiliation":[{"name":"Nexelis, a Q2 Solutions Company , 525 Boulevard Cartier Ouest, Laval, Quebec H7V 3S8, Canada"}]},{"given":"Caroline","family":"Atyeo","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT and Harvard , 400 Technology Square, Cambrige, MA 02139-3583, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-5557","authenticated-orcid":false,"given":"James A","family":"Overton","sequence":"additional","affiliation":[{"name":"Knocean Inc., 107 Quebec Ave. Toronto , Ontario, M6P 2T3, Canada"}]},{"given":"Randi","family":"Vita","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , 9420 Athena Circle, La Jolla, CA 92037, USA"}]},{"given":"Hector","family":"Guzman-Orozco","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , 9420 Athena Circle, La Jolla, CA 92037, USA"}]},{"given":"Marcus","family":"Mendes","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , 9420 Athena Circle, La Jolla, CA 92037, USA"}]},{"given":"Mari","family":"Kojima","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , 9420 Athena Circle, La Jolla, CA 92037, USA"}]},{"given":"Peter J","family":"Halfmann","sequence":"additional","affiliation":[{"name":"Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine , University of Wisconsin-Madison, WI 53711, 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S","family":"Baric","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive , 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, 125 Marson Farm Road , Chapel Hill, NC 27599-7290, USA"}]},{"given":"Georgia D","family":"Tomaras","sequence":"additional","affiliation":[{"name":"Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute , Duke University, Durham, NC 27701, USA"}]},{"given":"Tim","family":"Germann","sequence":"additional","affiliation":[{"name":"Carterra Inc., 825 N. 300 W.Ste, C309 , Salt Lake City, UT 84103, USA"}]},{"given":"Daniel","family":"Bedinger","sequence":"additional","affiliation":[{"name":"Carterra Inc., 825 N. 300 W.Ste, C309 , Salt Lake City, UT 84103, USA"}]},{"given":"Jason 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