{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T16:54:46Z","timestamp":1776012886325,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Saliva as a non-invasive diagnostic fluid has immense potential as a tool for early diagnosis and prognosis of patients. The information about salivary biomarkers is broadly scattered across various resources and research papers. It is important to bring together all the information on salivary biomarkers to a single platform. This will accelerate research and development in non-invasive diagnosis and prognosis of complex diseases. We collected widespread information on five types of salivary biomarkers\u2014proteins, metabolites, microbes, micro-ribonucleic acid (miRNA) and genes found in humans. This information was collected from different resources that include PubMed, the Human Metabolome Database and SalivaTecDB. Our database SalivaDB contains a total of 15\u2009821 entries for 201 different diseases and 48 disease categories. These entries can be classified into five categories based on the type of biomolecules; 6067, 3987, 2909, 2272 and 586 entries belong to proteins, metabolites, microbes, miRNAs and genes, respectively. The information maintained in this database includes analysis methods, associated diseases, biomarker type, regulation status, exosomal origin, fold change and sequence. The entries are linked to relevant biological databases to provide users with comprehensive information. We developed a web-based interface that provides a wide range of options like browse, keyword search and advanced search. In addition, a similarity search module has been integrated which allows users to perform a similarity search using Basic Local Alignment Search Tool and Smith\u2013Waterman algorithm against biomarker sequences in SalivaDB. We created a web-based database\u2014SalivaDB, which provides information about salivary biomarkers found in humans. A wide range of web-based facilities have been integrated to provide services to the scientific community. https:\/\/webs.iiitd.edu.in\/raghava\/salivadb\/<\/jats:p>","DOI":"10.1093\/database\/baad002","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T05:22:49Z","timestamp":1675747369000},"source":"Crossref","is-referenced-by-count":13,"title":["SalivaDB\u2014a comprehensive database for salivary biomarkers in humans"],"prefix":"10.1093","volume":"2023","author":[{"given":"Akanksha","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]},{"given":"Dashleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]},{"given":"Sumeet","family":"Patiyal","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]},{"given":"Dilraj","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]},{"given":"Ritu","family":"Tomer","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-2876","authenticated-orcid":false,"given":"Gajendra P S","family":"Raghava","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology , Okhla Phase 3, New Delhi 110020, India"}]}],"member":"286","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2023020705211317400_R1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/pgmj.2006.044792","article-title":"Post lumbar puncture headache: diagnosis and management","volume":"82","author":"Ahmed","year":"2006","journal-title":"Postgrad. Med. J."},{"key":"2023020705211317400_R2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2215\/CJN.04710420","article-title":"Systematic review and meta-analysis of native kidney biopsy complications","volume":"15","author":"Poggio","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2023020705211317400_R3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cden.2010.08.004","article-title":"Saliva as a diagnostic fluid","volume":"55","author":"Malamud","year":"2011","journal-title":"Dent. Clin. North Am."},{"key":"2023020705211317400_R4","article-title":"A review of selected studies that determine the physical and chemical properties of saliva in the field of dental treatment","volume":"(2018)","author":"Kubala","year":"2018","journal-title":"Biomed Res. Int."},{"key":"2023020705211317400_R5","first-page":"E449","article-title":"The r\u00f4le of saliva in maintaining oral health and as an aid to diagnosis","volume":"11","author":"Llena-Puy","year":"2006","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"2023020705211317400_R6","first-page":"303","article-title":"Saliva between normal and pathological. Important factors in determining systemic and oral health","volume":"2","author":"Iorgulescu","year":"2009","journal-title":"J. Med. Life"},{"key":"2023020705211317400_R7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008058","article-title":"The power of saliva: antimicrobial and beyond","volume":"15","author":"Vila","year":"2019","journal-title":"PLoS Pathog."},{"key":"2023020705211317400_R8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/physrev.00011.2011","article-title":"Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion","volume":"92","author":"Lee","year":"2012","journal-title":"Physiol. Rev."},{"key":"2023020705211317400_R9","article-title":"A new approach for the diagnosis of systemic and oral diseases based on salivary biomolecules","volume":"(2019)","author":"Roi","year":"2019","journal-title":"Dis. Markers"},{"key":"2023020705211317400_R10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/CMR.00021-13","article-title":"Salivary biomarkers: toward future clinical and diagnostic utilities","volume":"26","author":"Yoshizawa","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"2023020705211317400_R11","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"key":"2023020705211317400_R12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bjid.2020.08.001","article-title":"Saliva is a reliable, non-invasive specimen for SARS-CoV-2 detection","volume":"24","author":"Vaz","year":"2020","journal-title":"Braz. J. Infect. Dis."},{"key":"2023020705211317400_R13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1601-0825.2005.01187.x","article-title":"Oral transmission of HIV, reality or fiction? An update","volume":"12","author":"Campo","year":"2006","journal-title":"Oral Dis."},{"key":"2023020705211317400_R14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11306-009-0178-y","article-title":"Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles","volume":"6","author":"Sugimoto","year":"2010","journal-title":"Metabolomics"},{"key":"2023020705211317400_R15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cca.2015.05.008","article-title":"Investigation of salivary free amino acid profile for early diagnosis of breast cancer with ultra performance liquid chromatography-mass spectrometry","volume":"447","author":"Cheng","year":"2015","journal-title":"Clin. Chim. Acta."},{"key":"2023020705211317400_R16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015573","article-title":"Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"2023020705211317400_R17","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1177\/00220345211014432","article-title":"The Human Salivary Proteome Wiki: a community-driven research platform","volume":"100","author":"Lau","year":"2021","journal-title":"J. Dent. Res."},{"key":"2023020705211317400_R18","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.archoralbio.2012.12.012","article-title":"OralCard: a bioinformatic tool for the study of oral proteome","volume":"58","author":"Arrais","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"2023020705211317400_R19","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.archoralbio.2011.12.010","article-title":"From the salivary proteome to the OralOme: comprehensive molecular oral biology","volume":"57","author":"Rosa","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"2023020705211317400_R20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-01633-3","article-title":"CancerPDF: a repository of cancer-associated peptidome found in human biofluids","volume":"7","author":"Bhalla","year":"2017","journal-title":"Sci. Rep."},{"key":"2023020705211317400_R21","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the Human Metabolome Database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2023020705211317400_R22","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"Bateman","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023020705211317400_R23","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023020705211317400_R24","first-page":"D608","article-title":"NCBI Taxonomy: a comprehensive update on curation, resources and tools","volume":"(2020)","author":"Schoch","year":"2020","journal-title":"Database (Oxford)."},{"key":"2023020705211317400_R25","doi-asserted-by":"crossref","first-page":"D36","DOI":"10.1093\/nar\/gku1055","article-title":"Gene: a gene-centered information resource at NCBI","volume":"43","author":"Brown","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2023020705211317400_R26","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023020705211317400_R27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"2023020705211317400_R28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-2836(81)90087-5","article-title":"Identification of common molecular subsequences","volume":"147","author":"Smith","year":"1981","journal-title":"J. Mol. Biol."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad002\/49113025\/baad002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad002\/49113025\/baad002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T05:23:10Z","timestamp":1675747390000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baad002\/7030099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1093\/database\/baad002","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"baad002"}}