{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:35:44Z","timestamp":1771655744690,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":145,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007586","name":"Aix-Marseille University","doi-asserted-by":"publisher","award":["AMX-19-IET-007"],"award-info":[{"award-number":["AMX-19-IET-007"]}],"id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French Agency"},{"name":"Brazilian National Research Council"},{"name":"COFECUB","award":["Me987\/23"],"award-info":[{"award-number":["Me987\/23"]}]},{"DOI":"10.13039\/501100001677","name":"Inserm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2022\/00758-0"],"award-info":[{"award-number":["2022\/00758-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anr"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects \u223c7 million people worldwide. Per year, \u223c10\u2009000 people die from this pathology. Indeed, \u223c30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no treatment. In order to facilitate research on Chagas disease, a manual curation of all papers corresponding to \u2018Chagas disease\u2019 referenced on PubMed has been performed. All deregulated molecules in hosts (all mammals, humans, mice or others) following T. cruzi infection were retrieved and included in a database, named ChagasDB. A website has been developed to make this database accessible to all. In this article, we detail the construction of this database, its contents and how to use it.<\/jats:p>\n               <jats:p>Database URL https:\/\/chagasdb.tagc.univ-amu.fr<\/jats:p>","DOI":"10.1093\/database\/baad037","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T23:59:22Z","timestamp":1684886362000},"source":"Crossref","is-referenced-by-count":2,"title":["ChagasDB: 80 years of publicly available data on the molecular host response to <i>Trypanosoma cruzi<\/i> infection in a single database"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5812-0385","authenticated-orcid":false,"given":"Pauline","family":"Brochet","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-6371","authenticated-orcid":false,"given":"Jean-Christophe","family":"Mouren","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8160-1009","authenticated-orcid":false,"given":"Laurent","family":"Hannouche","sequence":"additional","affiliation":[{"name":"C2VN, INSERM, INRA, Aix Marseille Universit\u00e9 , Marseille 13005, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2401-0292","authenticated-orcid":false,"given":"Fabrice","family":"Lopez","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-7135","authenticated-orcid":false,"given":"Benoit","family":"Ballester","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3699-3345","authenticated-orcid":false,"given":"Edecio","family":"Cunha-Neto","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Heart Institute Instituto do Cora\u00e7\u00e3o (InCor), University of S\u00e3o Paulo, School of Medicine , S\u00e3o Paulo 05403-900, Brazil"},{"name":"Division of Clinical Immunology and Allergy, University of S\u00e3o Paulo, School of Medicine , S\u00e3o Paulo 05403-900, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia, INCT, III- Institute for Investigation in Immunology , S\u00e3o Paulo 05403-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-8141","authenticated-orcid":false,"given":"Lionel","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-8813","authenticated-orcid":false,"given":"Christophe","family":"Chevillard","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR)_1090, Aix Marseille Universit\u00e9, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa , Marseille 13288, France"}]}],"member":"286","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"2023052614340267900_R1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease","volume":"391","author":"P\u00e9rez-Molina","year":"2018","journal-title":"Lancet"},{"key":"2023052614340267900_R2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cytogfr.2021.10.001","article-title":"Chagas disease: Immunology of the disease at a glance","volume":"62","author":"Cristov\u00e3o-Silva","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023052614340267900_R3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"Lee","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"2023052614340267900_R4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0074-02762009000900025","article-title":"Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research","volume":"104 Suppl 1","author":"Scharfstein","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"2023052614340267900_R5","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1080\/17460441.2020.1806233","article-title":"Animal models of Chagas disease and their translational value to drug development","volume":"15","author":"Chatelain","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"key":"2023052614340267900_R6","doi-asserted-by":"crossref","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R7","doi-asserted-by":"crossref","first-page":"D939","DOI":"10.1093\/nar\/gkaa980","article-title":"Genenames.org: the HGNC and VGNC resources in 2021","volume":"49","author":"Tweedie","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R8","first-page":"1","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume-title":"Current Protocols in Bioinformatics","author":"Stelzer","year":"2016"},{"key":"2023052614340267900_R9","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R10","doi-asserted-by":"crossref","first-page":"D135","DOI":"10.1093\/nar\/gky1031","article-title":"LNCipedia 5: towards a reference set of human long non-coding RNAs","volume":"47","author":"Volders","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R11","doi-asserted-by":"crossref","first-page":"D981","DOI":"10.1093\/nar\/gkaa1083","article-title":"Mouse Genome Database (MGD): knowledgebase for mouse\u2013human comparative biology","volume":"49","author":"Blake","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R12","first-page":"D731","article-title":"The Year of the Rat: the Rat Genome Database at 20: a multi-species knowledgebase and analysis platform","volume":"48","author":"Smith","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R13","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"g:Profiler-a web server for functional interpretation of gene lists (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023052614340267900_R14","doi-asserted-by":"publisher","DOI":"10.17912\/micropub.biology.000811.","article-title":"rrvgo: a Bioconductor package for interpreting lists of Gene Ontology terms","volume":"2023","author":"Sayols","year":"2023","journal-title":"MicroPubl. Biol."},{"key":"2023052614340267900_R15","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad037\/50457553\/baad037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad037\/50457553\/baad037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T14:34:44Z","timestamp":1685111684000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baad037\/7176384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1093\/database\/baad037","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"baad037"}}