{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:21:01Z","timestamp":1758892861900,"version":"3.41.2"},"reference-count":87,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":282,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u2018Esophageal cancer\u2019 (EC) is a highly aggressive and deadly complex disease. It comprises two types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), with Barrett\u2019s esophagus (BE) being the only known precursor. Recent research has revealed that microRNAs (miRNAs) play a crucial role in the development, prognosis and treatment of EC and are involved in various human diseases. Biological databases have become essential for cancer research as they provide information on genes, proteins, pathways and their interactions. These databases collect, store and manage large amounts of molecular data, which can be used to identify patterns, predict outcomes and generate hypotheses. However, no comprehensive database exists for EC and miRNA relationships. To address this gap, we developed a dynamic database named \u2018ESOMIR (miRNA in esophageal cancer) (https:\/\/esomir.dqweilab-sjtu.com)\u2019, which includes information about targeted genes and miRNAs associated with EC. The database uses analysis and prediction methods, including experimentally endorsed miRNA(s) information. ESOMIR is a user-friendly interface that allows easy access to EC-associated data by searching for miRNAs, target genes, sequences, chromosomal positions and associated signaling pathways. The search modules are designed to provide specific data access to users based on their requirements. Additionally, the database provides information about network interactions, signaling pathways and region information of chromosomes associated with the 3\u02b9untranslated region (3\u02b9UTR) or 5\u02b9UTR and exon sites. Users can also access energy levels of specific miRNAs with targeted genes. A fuzzy term search is included in each module to enhance the ease of use for researchers. ESOMIR can be a valuable tool for researchers and clinicians to gain insight into EC, including identifying biomarkers and treatments for this aggressive tumor.<\/jats:p>\n               <jats:p>Database URL https:\/\/esomir.dqweilab-sjtu.com<\/jats:p>","DOI":"10.1093\/database\/baad063","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:40:53Z","timestamp":1696948853000},"source":"Crossref","is-referenced-by-count":4,"title":["ESOMIR: a curated database of\u00a0biomarker genes and\u00a0miRNAs associated with esophageal cancer"],"prefix":"10.1093","volume":"2023","author":[{"given":"Asma","family":"Sindhoo","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Dongchuan Road Minhang District, Shanghai 200240, PR China"}]},{"given":"Saima","family":"Sipy","sequence":"additional","affiliation":[{"name":"Sindh Madressatul Islam University , Karachi, Sindh 74600, Pakistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-7602","authenticated-orcid":false,"given":"Abbas","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Dongchuan Road Minhang District, Shanghai 200240, PR China"},{"name":"State Key Laboratory of Microbial Metabolism, Shanghai\u2013Islamabad\u2013Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology , Shanghai, Minhang 200030, PR China"}]},{"given":"Gurudeeban","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Centre for Research in Molecular Modelling (CERMM), Department of Chemistry and Biochemistry, Concordia University , Montreal, Quebec H4B 1R6, Canada"}]},{"given":"Abdulrahman","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh 11451, Saudi Arabia"}]},{"given":"Mark Earl","family":"Casida","sequence":"additional","affiliation":[{"name":"Laboratoire de Spectrom\u00b4etrie, Interactions et Chimie th\u00b4eorique (SITh), D\u00b4epartement de Chimie Mol\u00b4eculaire (DCM, UMR CNRS\/UGA 5250), Institut de Chimie Mol\u00b4eculaire de Grenoble (ICMG, FR2607), Universit\u00b4e Grenoble Alpes (UGA) , 301 rue de la Chimie BP 53, Grenoble Cedex F-38041, France"}]},{"given":"Dong-Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Dongchuan Road Minhang District, Shanghai 200240, PR China"},{"name":"State Key Laboratory of Microbial Metabolism, Shanghai\u2013Islamabad\u2013Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology , Shanghai, Minhang 200030, PR China"},{"name":"Peng Cheng Laboratory , Phase I Building 8, Xili Street, Montreal, Vanke Cloud City, Nashan District, Shenzhen, Guangdong 518055, PR China"}]}],"member":"286","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"2023101014401392300_R1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of\u00a0incidence and\u00a0mortality worldwide for\u00a036 cancers in\u00a0185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"2023101014401392300_R2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.athoracsur.2012.01.064","article-title":"Comparative genomics of\u00a0esophageal adenocarcinoma and\u00a0squamous cell carcinoma","volume":"93","author":"Bandla","year":"2012","journal-title":"Ann. Thorac. Surg."},{"key":"2023101014401392300_R3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.canep.2015.10.013","article-title":"The impact of\u00a0lifestyle on\u00a0Barrett\u2019s esophagus: a precursor to esophageal adenocarcinoma","volume":"39","author":"Navab","year":"2015","journal-title":"Cancer Epidemiol."},{"key":"2023101014401392300_R4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of\u00a0oesophageal carcinoma","volume":"541","author":"Network","year":"2017","journal-title":"Nature"},{"key":"2023101014401392300_R5","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3748\/wjg.v21.i26.7933","article-title":"Esophageal cancer: risk factors, screening and\u00a0endoscopic treatment in\u00a0western and\u00a0eastern countries","volume":"21","author":"Arnal","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"2023101014401392300_R6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.genom.8.080706.092419","article-title":"Annotating noncoding RNA genes","volume":"8","author":"Griffiths-Jones","year":"2007","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"2023101014401392300_R7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and\u00a0regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"2023101014401392300_R8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"MicroRNAs as oncogenes and\u00a0tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev. Biol."},{"key":"2023101014401392300_R9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1469-185X.2008.00061.x","article-title":"The roles of\u00a0microRNA in\u00a0cancer and\u00a0apoptosis","volume":"84","author":"Lynam-Lennon","year":"2009","journal-title":"Biol. Rev."},{"key":"2023101014401392300_R10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2174\/1389201015666140519095304","article-title":"MicroRNAs and\u00a0cancer; an overview","volume":"15","author":"Tutar","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2023101014401392300_R11","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and\u00a0genomic regions involved in\u00a0cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023101014401392300_R12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.21037\/acs.2017.03.03","article-title":"Overview of\u00a0esophageal cancer","volume":"6","author":"Abbas","year":"2017","journal-title":"Ann. Cardiothorac. Surg."},{"key":"2023101014401392300_R13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7150\/jca.13332","article-title":"Survivin and\u00a0tumorigenesis: molecular mechanisms and\u00a0therapeutic strategies","volume":"7","author":"Chen","year":"2016","journal-title":"J. Cancer"},{"key":"2023101014401392300_R14","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.3390\/ijms140714771","article-title":"Clinical advances in\u00a0molecular biomarkers for\u00a0cancer diagnosis and\u00a0therapy","volume":"14","author":"Sethi","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"2023101014401392300_R15","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1158\/1940-6207.CAPR-11-0441","article-title":"The state of\u00a0molecular biomarkers for\u00a0the early detection of\u00a0lung cancer","volume":"5","author":"Hassanein","year":"2012","journal-title":"Cancer Prevent. Res."},{"key":"2023101014401392300_R16","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.3748\/wjg.v21.i37.10573","article-title":"Biomarkers for\u00a0the early diagnosis of\u00a0hepatocellular carcinoma","volume":"21","author":"Tsuchiya","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"2023101014401392300_R17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2020.00881","article-title":"Integrated PPI- and\u00a0WGCNA-retrieval of\u00a0hub gene signatures shared between Barrett\u2019s esophagus and\u00a0esophageal adenocarcinoma","volume":"11","author":"Nangraj","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2023101014401392300_R18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jpm10040162","article-title":"Circulating mir-1246 targeting UBE2C, TNNI3, TRAIP, UCHL1 genes and\u00a0key pathways as a potential biomarker for\u00a0lung adenocarcinoma: integrated biological network analysis","volume":"10","author":"Huang","year":"2020","journal-title":"J. Pers. Med."},{"key":"2023101014401392300_R19","first-page":"1397","article-title":"A novel microRNA signature for\u00a0pathological grading in\u00a0lung adenocarcinoma based on\u00a0TCGA and\u00a0GEO data","volume":"45","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"2023101014401392300_R20","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00374","article-title":"Prognostic genes of\u00a0breast cancer identified by gene co-expression network analysis","volume":"8","author":"Tang","year":"2018","journal-title":"Front. Oncol."},{"key":"2023101014401392300_R21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prp.2019.03.004","article-title":"The expression of\u00a0mir-375 in\u00a0prostate cancer: a study based on\u00a0GEO, TCGA data and\u00a0bioinformatics analysis","volume":"215","author":"He","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"2023101014401392300_R22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2004-5-2-p5","article-title":"Computational identification of\u00a0microRNA targets","volume":"5","author":"Rajewsky","year":"2004","journal-title":"Genome Biol."},{"key":"2023101014401392300_R23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jtcvs.2007.08.055","article-title":"MicroRNA expression profiles of\u00a0esophageal cancer","volume":"135","author":"Feber","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"2023101014401392300_R24","first-page":"459","article-title":"MicroRNAs in\u00a0esophageal cancer","volume":"6","author":"He","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"2023101014401392300_R25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00535-016-1161-9","article-title":"The role of\u00a0microRNA in\u00a0esophageal squamous cell carcinoma","volume":"51","author":"Harada","year":"2016","journal-title":"J. Gastroenterol."},{"key":"2023101014401392300_R26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3233\/CBM-190736","article-title":"MicroRNA-105 plays an independent prognostic role in\u00a0esophageal cancer and\u00a0acts as an oncogene","volume":"27","author":"Gao","year":"2020","journal-title":"Cancer Biomark."},{"key":"2023101014401392300_R27","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1007\/s10620-013-2806-7","article-title":"MicroRNA expression differentiates squamous epithelium from Barrett\u2019s esophagus and\u00a0esophageal cancer","volume":"58","author":"Garman","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"2023101014401392300_R28","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"Enright, miRBase: microRNA sequences, targets and\u00a0gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R29","doi-asserted-by":"crossref","first-page":"D190","DOI":"10.1093\/nar\/gkv1254","article-title":"DIANA-miRGen v3.0: accurate characterization of\u00a0microRNA promoters and\u00a0their regulators","volume":"44","author":"Georgakilas","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R30","doi-asserted-by":"crossref","first-page":"D252","DOI":"10.1093\/nar\/gks1168","article-title":"Mirgator v3.0: a microRNA portal for\u00a0deep sequencing, expression profiling and\u00a0mRNA targeting","volume":"41","author":"Cho","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: an online resource for\u00a0prediction of\u00a0microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS One"},{"key":"2023101014401392300_R32","first-page":"D148","article-title":"miRTarBase 2020: updates to the experimentally validated microRNA\u2013target interaction database","volume":"48","author":"Huang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R33","doi-asserted-by":"crossref","first-page":"D135","DOI":"10.1093\/nar\/gkj135","article-title":"miRNAMap: genomic maps of\u00a0microRNA genes and\u00a0their target genes in\u00a0mammalian genomes","volume":"1","author":"Hsu","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R34","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.1093\/nar\/gkn851","article-title":"miRecords: an integrated resource for\u00a0microRNA\u2013target interactions","volume":"37","author":"Xiao","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in\u00a0mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"2023101014401392300_R36","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gku1104","article-title":"miRDB: an online resource for\u00a0microRNA target prediction and\u00a0functional annotations","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"2023101014401392300_R38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2019.01330","article-title":"Improving bioinformatics prediction of\u00a0microRNA targets by ranks aggregation","volume":"10","author":"Quillet","year":"2020","journal-title":"Front. Genet."},{"key":"2023101014401392300_R39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-15-15","article-title":"OncomiRdbB: a comprehensive database of\u00a0microRNAs and\u00a0their targets in\u00a0breast cancer","volume":"15","author":"Khurana","year":"2014","journal-title":"BMC Bioinform."},{"key":"2023101014401392300_R40","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/bioinformatics\/btt014","article-title":"miRCancer: a microRNA\u2013cancer association database constructed by text mining on\u00a0literature","volume":"29","author":"Xie","year":"2013","journal-title":"Bioinformatics"},{"key":"2023101014401392300_R41","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa089","article-title":"miRactDB characterizes miRNA\u2013gene relation switch between normal and\u00a0cancer tissues across pan-cancer","volume":"22","author":"Tan","year":"2021","journal-title":"Brief. Bioinform."},{"key":"2023101014401392300_R42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2010-11-1-r6","article-title":"PhenomiR: a knowledgebase for\u00a0microRNA expression in\u00a0diseases and\u00a0biological processes","volume":"11","author":"Ruepp","year":"2010","journal-title":"Genome Biol."},{"key":"2023101014401392300_R43","doi-asserted-by":"crossref","first-page":"D1070","DOI":"10.1093\/nar\/gkt1023","article-title":"HMDD v2.0: a database for\u00a0experimentally supported human microRNA and\u00a0disease associations","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/labinvest.2010.53","article-title":"S-MED: sarcoma microRNA expression database","volume":"90","author":"Sarver","year":"2010","journal-title":"Lab. Invest."},{"key":"2023101014401392300_R45","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","article-title":"mir2disease: a manually curated database for\u00a0microRNA deregulation in\u00a0human disease","volume":"37","author":"Jiang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R46","first-page":"1","article-title":"miRSystem: an integrated system for\u00a0characterizing enriched functions and\u00a0pathways of\u00a0microRNA targets","volume":"7","author":"Lu","year":"2012","journal-title":"PLoS One"},{"key":"2023101014401392300_R47","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/sj.bjc.6602928","article-title":"COSMIC 2005","volume":"94","author":"Forbes","year":"2006","journal-title":"Br. J. Cancer"},{"key":"2023101014401392300_R48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of\u00a0Genes and\u00a0Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-9-219","article-title":"DDEC: Dragon database of\u00a0genes implicated in\u00a0esophageal cancer","volume":"9","author":"Essack","year":"2009","journal-title":"BMC Cancer"},{"key":"2023101014401392300_R50","doi-asserted-by":"crossref","first-page":"D533","DOI":"10.1093\/nar\/gki117","article-title":"Cancer gene expression database (CGED): a database for\u00a0gene expression profiling with accompanying clinical information of\u00a0human cancer tissues","volume":"33","author":"Kato","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R51","first-page":"D845","article-title":"The DisGeNET knowledge platform for\u00a0disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R52","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bar030","article-title":"Ensembl BioMarts: a hub for\u00a0data retrieval across taxonomic space","volume":"2011","author":"Kinsella","year":"2011","journal-title":"Database"},{"key":"2023101014401392300_R53","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for\u00a0the identification of\u00a0microRNA binding sites and\u00a0their corresponding heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"2023101014401392300_R54","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkt393","article-title":"DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows","volume":"41","author":"Paraskevopoulou","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023101014401392300_R55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12094-012-0774-6","article-title":"JAK\/STAT signal pathway activation promotes progression and\u00a0survival of\u00a0human oesophageal squamous cell carcinoma","volume":"14","author":"You","year":"2012","journal-title":"Clin. Transl. Oncol."},{"key":"2023101014401392300_R56","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1590\/1414-431X20143906","article-title":"Expression analysis of\u00a0miRNA and\u00a0target mRNAs in\u00a0esophageal cancer","volume":"47","author":"Meng","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"key":"2023101014401392300_R57","first-page":"814","article-title":"Effects of\u00a0MiR-210 on\u00a0proliferation, apoptosis and\u00a0invasion abilities of\u00a0esophageal cancer cells","volume":"23","author":"Cheng","year":"2018","journal-title":"J. BUON"},{"key":"2023101014401392300_R58","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.2174\/1381612825666190110143258","article-title":"The esophageal cancer and\u00a0the PI3K\/AKT\/mTOR signaling regulatory microRNAs: a novel marker for\u00a0prognosis, and\u00a0a possible target for\u00a0immunotherapy","volume":"24","author":"Javadinia","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"2023101014401392300_R59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2021.119984","article-title":"Crosstalk between miRNA and\u00a0PI3K\/AKT\/mTOR signaling pathway in\u00a0cancer","volume":"285","author":"Akbarzadeh","year":"2021","journal-title":"Life Sci."},{"key":"2023101014401392300_R60","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.biopha.2018.07.129","article-title":"Long non-coding RNA FTH1P3 regulated metastasis and\u00a0invasion of\u00a0esophageal squamous cell carcinoma through SP1\/NF-kB pathway","volume":"106","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"2023101014401392300_R61","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/1724600819827964","article-title":"MicroRNA-373 promotes the development of\u00a0esophageal squamous cell carcinoma by targeting LATS2 and\u00a0OXR1","volume":"34","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Markers"},{"key":"2023101014401392300_R62","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1007\/s13277-014-1968-z","article-title":"Nicotine upregulates microRNA-21 and\u00a0promotes TGF-\u03b2-dependent epithelial-mesenchymal transition of\u00a0esophageal cancer cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumor Biol."},{"key":"2023101014401392300_R63","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jmoldx.2012.06.004","article-title":"Inhibition of\u00a0SOX17 by microRNA 141 and\u00a0methylation activates the WNT signaling pathway in\u00a0esophageal cancer","volume":"14","author":"Jia","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"2023101014401392300_R64","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.12998\/wjcc.v10.i9.2678","article-title":"Roles of\u00a0Wnt\/\u03b2-catenin signaling pathway related microRNAs in\u00a0esophageal cancer","volume":"10","author":"Chu","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"2023101014401392300_R65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0030590","article-title":"Curcumin induces cell death in\u00a0esophageal cancer cells through modulating notch signaling","volume":"7","author":"Subramaniam","year":"2012","journal-title":"PLoS One"},{"key":"2023101014401392300_R66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/baab031","article-title":"emiRIT: a text-mining-based resource for\u00a0microRNA information","volume":"2021","author":"Roychowdhury","year":"2021","journal-title":"Database"},{"key":"2023101014401392300_R67","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nmeth0609-397","article-title":"Predicting microRNA targets and\u00a0functions: traps for\u00a0the unwary","volume":"6","author":"Ritchie","year":"2009","journal-title":"Nat. Methods"},{"key":"2023101014401392300_R68","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of\u00a0mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"2023101014401392300_R69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-15-S7-S4","article-title":"Identifying microRNA targets in\u00a0different gene regions","volume":"15","author":"Xu","year":"2014","journal-title":"BMC Bioinform."},{"key":"2023101014401392300_R70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-030-55031-8_5","article-title":"NOTCH and\u00a0esophageal squamous cell carcinoma","volume":"1287","author":"Li","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"2023101014401392300_R71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-017-0622-1","article-title":"Downregulation of\u00a0MiR-31 stimulates expression of\u00a0LATS2 via the hippo pathway and\u00a0promotes epithelial-mesenchymal transition in\u00a0esophageal squamous cell carcinoma","volume":"36","author":"Gao","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2023101014401392300_R72","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.7150\/jca.39861","article-title":"MiR-34a-5p inhibits proliferation, migration, invasion and\u00a0epithelial-mesenchymal transition in\u00a0esophageal squamous cell carcinoma by targeting lef1 and\u00a0inactivation of\u00a0the Hippo-YAP1\/TAZ signaling pathway","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"2023101014401392300_R73","doi-asserted-by":"crossref","first-page":"12061","DOI":"10.1007\/s13277-016-5074-2","article-title":"MicroRNA-21 promotes cell proliferation, migration, and\u00a0resistance to apoptosis through PTEN\/PI3K\/AKT signaling pathway in\u00a0esophageal cancer","volume":"37","author":"Wu","year":"2016","journal-title":"Tumor Biol."},{"key":"2023101014401392300_R74","doi-asserted-by":"crossref","first-page":"10065","DOI":"10.1200\/jco.2006.24.18_suppl.10065","article-title":"Transcription factor NFkB a potential molecular marker for\u00a0predicting and\u00a0improving treatment efficacy in\u00a0esophageal cancer","volume":"24","author":"Izzo","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"2023101014401392300_R75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-13-4","article-title":"Transcriptional activation of\u00a0microRNA-34a by NF-kappa B in\u00a0human esophageal cancer cells","volume":"13","author":"Li","year":"2012","journal-title":"BMC Mol. Biol."},{"key":"2023101014401392300_R76","first-page":"459","article-title":"Notch receptor inhibition reveals the importance of\u00a0cyclin D1 and\u00a0Wnt signaling in\u00a0invasive esophageal squamous cell carcinoma","volume":"2","author":"Naganuma","year":"2012","journal-title":"Am. J. Cancer Res."},{"key":"2023101014401392300_R77","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.3748\/wjg.v23.i45.7965","article-title":"Down-regulation of\u00a0miR-30a-3p\/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway","volume":"23","author":"Qi","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"2023101014401392300_R78","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/ijc.25284","article-title":"miR-145, miR-133a and\u00a0miR-133b: tumor-suppressive miRNAs target FSCN1 in\u00a0esophageal squamous cell carcinoma","volume":"127","author":"Kano","year":"2010","journal-title":"Int. J. Cancer"},{"key":"2023101014401392300_R79","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000310918","article-title":"MicroRNAs and\u00a0esophageal squamous cell carcinoma","volume":"82","author":"Matsushima","year":"2010","journal-title":"Digestion"},{"key":"2023101014401392300_R80","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1007\/s11033-010-0480-9","article-title":"Role of\u00a0microRNA-21 and\u00a0effect on\u00a0PTEN in\u00a0Kazakh\u2019s esophageal squamous cell carcinoma","volume":"38","author":"Ma","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"2023101014401392300_R81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-9-30","article-title":"miRNA-205 modulates cellular invasion and\u00a0migration via regulating zinc finger E-box binding homeobox 2 expression in\u00a0esophageal squamous cell carcinoma cells","volume":"9","author":"Matsushima","year":"2011","journal-title":"J. Transl. Med."},{"key":"2023101014401392300_R82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1747-1028-2-24","article-title":"Fez1\/Lzts1 a new mitotic regulator implicated in\u00a0cancer development","volume":"2","author":"Vecchione","year":"2007","journal-title":"Cell Div."},{"key":"2023101014401392300_R83","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/cbin.10588","article-title":"FGF2 regulates proliferation, migration, and\u00a0invasion of\u00a0ECA109 cells through PI3K\/Akt signalling pathway in\u00a0vitro","volume":"40","author":"Shi","year":"2016","journal-title":"Cell Biol. Int."},{"key":"2023101014401392300_R84","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1002\/ijc.23434","article-title":"DCC promoter hypermethylation in\u00a0esophageal squamous cell carcinoma","volume":"122","author":"Lui Park","year":"2008","journal-title":"Int. J. Cancer"},{"key":"2023101014401392300_R85","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1349-7006.1999.tb00809.x","article-title":"Mxi1 mutations in\u00a0human neurofibrosarcomas","volume":"90","author":"Li","year":"1999","journal-title":"Jpn. J. Cancer Res."},{"key":"2023101014401392300_R86","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1158\/0008-5472.CAN-04-3247","article-title":"Genome-wide association study in\u00a0esophageal cancer using GeneChip mapping 10k array","volume":"65","author":"Hu","year":"2005","journal-title":"Cancer Res."},{"key":"2023101014401392300_R87","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00432-007-0290-1","article-title":"TGFB1 and\u00a0TGFBR2 functional polymorphisms and\u00a0risk of\u00a0esophageal squamous cell carcinoma: a case\u2013control analysis in\u00a0a Chinese population","volume":"134","author":"Jin","year":"2008","journal-title":"J. Cancer Res. Clin. Oncol."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad063\/51990481\/baad063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad063\/51990481\/baad063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:42:10Z","timestamp":1696948930000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baad063\/7303975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":87,"URL":"https:\/\/doi.org\/10.1093\/database\/baad063","relation":{},"ISSN":["1758-0463"],"issn-type":[{"type":"electronic","value":"1758-0463"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"baad063"}}