{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:14Z","timestamp":1753875974779,"version":"3.41.2"},"reference-count":51,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":272,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222097"],"award-info":[{"award-number":["L222097"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for High-Level Overseas Talents, Beihang University"},{"name":"Youth Thousand Scholar Program of China"},{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222097"],"award-info":[{"award-number":["L222097"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for High-Level Overseas Talents, Beihang University"},{"name":"Youth Thousand Scholar Program of China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The 2019 Novel Coronavirus (SARS-CoV-2) has infected millions of people worldwide and caused millions of deaths. The virus has gone numerous mutations to replicate faster, which can overwhelm the immune system of the host. Linear B-cell epitopes are becoming promising in prevention of various deadly infectious diseases, breaking the general idea of their low immunogenicity and partial protection. However, there is still no public repository to host the linear B-cell epitopes for facilitating the development vaccines against SARS-CoV-2. Therefore, we developed BCEDB, a linear B-cell epitopes database specifically designed for hosting, exploring and visualizing linear B-cell epitopes and their features. The database provides a comprehensive repository of computationally predicted linear B-cell epitopes from Spike protein; a systematic annotation of epitopes including sequence, antigenicity score, genomic locations of epitopes, mutations in different virus lineages, mutation sites on the 3D structure of Spike protein and a genome browser to visualize them in an interactive manner. It represents a valuable resource for peptide-based vaccine development.<\/jats:p>\n               <jats:p>Database URL: http:\/\/www.oncoimmunobank.cn\/bcedbindex<\/jats:p>","DOI":"10.1093\/database\/baad065","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T18:47:41Z","timestamp":1696099661000},"source":"Crossref","is-referenced-by-count":2,"title":["BCEDB: a linear B-cell epitopes database for\u00a0SARS-CoV-2"],"prefix":"10.1093","volume":"2023","author":[{"given":"Chengzheng","family":"Tai","sequence":"first","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University , No. 37 Xueyuan Road, Haidian District, Beijing 100191, China"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing YouAn Hospital, Capital Medical University , No. 8 Youan Gate Outer Xitou Alley, Beijing 100069, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-3286","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University , No. 37 Xueyuan Road, Haidian District, Beijing 100191, China"}]}],"member":"286","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"2023093018461920200_R1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and\u00a0naming it SARS-CoV-2","volume":"5","author":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses","year":"2020","journal-title":"Nat. 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