{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:35:14Z","timestamp":1768592114714,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":330,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108014 82071407 82171396 82271434"],"award-info":[{"award-number":["81820108014 82071407 82171396 82271434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108014 82071407 82171396 82271434"],"award-info":[{"award-number":["81820108014 82071407 82171396 82271434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Programmed cell death (PCD) refers to controlled cell death that is conducted to keep the internal environment stable. Long noncoding RNAs (lncRNAs) participate in the progression of PCD in a variety of diseases. However, no specialized online repository is available to collect and store the associations between lncRNA-mediated PCD and diseases. Here, we developed LncPCD, a comprehensive database that provides information on experimentally supported associations of lncRNA-mediated PCD with diseases. The current version of LncPCD documents 6666 associations between five common types of PCD (apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis) and 1222 lncRNAs in 331 diseases. We also manually curated a wealth of information: (1) 7 important lncRNA regulatory mechanisms, (2) 310 PCD-associated cell types in three species, (3) detailed information on lncRNA subcellular locations and (4) clinical applications for lncRNA-mediated PCD in diseases. Additionally, 10 single-cell sequencing datasets were integrated into LncPCD to characterize the dynamics of lncRNAs in diseases. Overall, LncPCD is an extremely useful resource for understanding the functions and mechanisms of lncRNA-mediated PCD in diseases.<\/jats:p>\n               <jats:p>Database URL: \u00a0http:\/\/spare4.hospital.studio:9000\/lncPCD\/Home.jsp<\/jats:p>","DOI":"10.1093\/database\/baad087","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:22:33Z","timestamp":1701127353000},"source":"Crossref","is-referenced-by-count":4,"title":["LncPCD: a manually curated database of\u00a0experimentally supported associations between lncRNA-mediated programmed cell death and\u00a0diseases"],"prefix":"10.1093","volume":"2023","author":[{"given":"Ni","family":"He","sequence":"first","affiliation":[]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Fanfan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Jingnan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Lifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Liting","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Biying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Xiaoju","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-8945","authenticated-orcid":false,"given":"Shangwei","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"},{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-4612","authenticated-orcid":false,"given":"Jianjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]}],"member":"286","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"2023112720542414300_R1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and\u00a0apoptosis: an intricate game of\u00a0cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"2023112720542414300_R2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of\u00a0cell death: recommendations of\u00a0the Nomenclature Committee on\u00a0Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"2023112720542414300_R3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of\u00a0regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"2023112720542414300_R4","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-021-02101-7","article-title":"Pyroptosis: a new paradigm of\u00a0cell death for\u00a0fighting against cancer","volume":"40","author":"Tan","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2023112720542414300_R5","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108010","article-title":"Programming inflammatory cell death for\u00a0therapy","volume":"232","author":"Christgen","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"2023112720542414300_R6","article-title":"Programmed cell death in\u00a0atherosclerosis and\u00a0vascular calcification","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"2023112720542414300_R7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of\u00a0the major forms of\u00a0apoptosis, necrosis and\u00a0autophagy","volume":"43","author":"D\u2019Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"2023112720542414300_R8","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-023-00748-2","article-title":"Monotropein attenuates apoptosis and\u00a0pyroptosis in\u00a0chondrocytes and\u00a0alleviates osteoarthritis progression in\u00a0mice","volume":"18","author":"Li","year":"2023","journal-title":"Chin. Med."},{"key":"2023112720542414300_R9","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-021-00407-1","article-title":"Progress in\u00a0understanding the role of\u00a0lncRNA in\u00a0programmed cell death","volume":"7","author":"Jiang","year":"2021","journal-title":"Cell Death Discov."},{"key":"2023112720542414300_R10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"2023112720542414300_R11","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and\u00a0epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol. Cell"},{"key":"2023112720542414300_R12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in\u00a0a manner dependent upon apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"key":"2023112720542414300_R13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.biopha.2018.05.056","article-title":"Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of\u00a0proliferation and\u00a0invasion by competitively binding miR-196a-5p","volume":"104","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"2023112720542414300_R14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15384101.2021.2019411","article-title":"Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and\u00a0apoptosis of\u00a0chondrocytes in\u00a0osteoarthritis","volume":"21","author":"Wen","year":"2022","journal-title":"Cell Cycle"},{"key":"2023112720542414300_R15","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113139","article-title":"Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485\/AIM2 axis","volume":"325","author":"Liang","year":"2020","journal-title":"Exp. Neurol."},{"key":"2023112720542414300_R16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/cdd.2009.215","article-title":"DeathBase: a database on\u00a0structure, evolution and\u00a0function of\u00a0proteins involved in\u00a0apoptosis and\u00a0other forms of\u00a0cell death","volume":"17","author":"D\u00edez","year":"2010","journal-title":"Cell Death Differ."},{"key":"2023112720542414300_R17","doi-asserted-by":"crossref","first-page":"D986","DOI":"10.1093\/nar\/gkq995","article-title":"The Autophagy Database: an all-inclusive information resource on\u00a0autophagy that provides nourishment for\u00a0research","volume":"39","author":"Homma","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R18","doi-asserted-by":"crossref","DOI":"10.1186\/s13321-018-0289-4","article-title":"HAMdb: a database of\u00a0human autophagy modulators with specific pathway and\u00a0disease information","volume":"10","author":"Wang","year":"2018","journal-title":"J. Cheminform."},{"key":"2023112720542414300_R19","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaa021","article-title":"FerrDb: a manually curated resource for\u00a0regulators and\u00a0markers of\u00a0ferroptosis and\u00a0ferroptosis-disease associations","volume":"2020","author":"Zhou","year":"2020","journal-title":"Database (Oxford)"},{"key":"2023112720542414300_R20","doi-asserted-by":"crossref","first-page":"D571","DOI":"10.1093\/nar\/gkac935","article-title":"FerrDb V2: update of\u00a0the manually curated database of\u00a0ferroptosis regulators and\u00a0ferroptosis-disease associations","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R21","doi-asserted-by":"crossref","first-page":"D181","DOI":"10.1093\/nar\/gkx1035","article-title":"MSDD: a manually curated database of\u00a0experimentally supported associations among miRNAs, SNPs and\u00a0human diseases","volume":"46","author":"Yue","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R22","first-page":"D118","article-title":"LncTarD: a manually-curated database of\u00a0experimentally-supported functional lncRNA-target regulations in\u00a0human diseases","volume":"48","author":"Zhao","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R23","doi-asserted-by":"crossref","first-page":"D212","DOI":"10.1093\/nar\/gkaa921","article-title":"RNAcentral 2021: secondary structure integration, improved sequence search and\u00a0new member databases","volume":"49","author":"Sweeney","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R24","doi-asserted-by":"crossref","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R25","doi-asserted-by":"crossref","first-page":"D1255","DOI":"10.1093\/nar\/gkab1063","article-title":"The Human Disease Ontology 2022 update","volume":"50","author":"Schriml","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R26","doi-asserted-by":"crossref","first-page":"D125","DOI":"10.1093\/nar\/gkaa1017","article-title":"LnCeCell: a comprehensive database of\u00a0predicted lncRNA-associated ceRNA networks at single-cell resolution","volume":"49","author":"Wang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R27","doi-asserted-by":"crossref","first-page":"D333","DOI":"10.1093\/nar\/gkab825","article-title":"RNALocate v2.0: an updated resource for\u00a0RNA subcellular localization with increased coverage and\u00a0annotation","volume":"50","author":"Cui","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023112720542414300_R28","article-title":"Programmed cell death tunes tumor immunity","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"2023112720542414300_R29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2478\/s11658-014-0212-6","article-title":"Regulation of\u00a0lncRNA expression","volume":"19","author":"Wu","year":"2014","journal-title":"Cell Mol. Biol. Lett."},{"key":"2023112720542414300_R30","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00018-016-2174-5","article-title":"Mechanisms of\u00a0long noncoding RNA function in\u00a0development and\u00a0disease","volume":"73","author":"Schmitz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"2023112720542414300_R31","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/jcb.30221","article-title":"The various regulatory functions of\u00a0long noncoding RNAs in\u00a0apoptosis, cell cycle, and\u00a0cellular senescence","volume":"123","author":"Heydarnezhad Asl","year":"2022","journal-title":"J. Cell Biochem."},{"key":"2023112720542414300_R32","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/15548627.2021.1883881","article-title":"Exploring the role of\u00a0non-coding RNAs in\u00a0autophagy","volume":"18","author":"Ghafouri-Fard","year":"2022","journal-title":"Autophagy"},{"key":"2023112720542414300_R33","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.7150\/ijbs.66917","article-title":"Ferroptosis in\u00a0cancer progression: role of\u00a0noncoding RNAs","volume":"18","author":"Zuo","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"2023112720542414300_R34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cca.2019.11.035","article-title":"Long non-coding RNAs and\u00a0pyroptosis","volume":"504","author":"He","year":"2020","journal-title":"Clin. Chim. Acta"}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad087\/53831330\/baad087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baad087\/53831330\/baad087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:22:55Z","timestamp":1701127375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baad087\/7451593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1093\/database\/baad087","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"baad087"}}