{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:28:32Z","timestamp":1783646912060,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NEI","award":["P30-EY031631 R01-EY029728"],"award-info":[{"award-number":["P30-EY031631 R01-EY029728"]}]},{"name":"NIH\/NEI","award":["P30-EY031631 R01-EY029728"],"award-info":[{"award-number":["P30-EY031631 R01-EY029728"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aqueous humor (AH) is a low-viscosity biofluid that continuously circulates from the posterior chamber to the anterior chamber of the eye. Recent advances in high-resolution mass-spectrometry workflows have facilitated the study of proteomic content in small-volume biofluids like AH, highlighting the potential clinical implications of the AH proteome. Nevertheless, in-depth investigations into the role of AH proteins in ocular diseases have encountered challenges due to limited accessibility to these workflows, difficulties in large-scale AH sample collection and the absence of a reference AH proteomic database. In response to these obstacles, and to promote further research on the involvement of AH proteins in ocular physiology and pathology, we have developed the web-based Aqueous Humor Proteomics Database (AHP DB). The current version of AHP DB contains proteomic data from 307 human AH samples, which were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS\/MS). The database offers comprehensive information on 1683 proteins identified in the AH samples. Furthermore, relevant clinical data are provided for each analyzed sample. Researchers also have the option to download these datasets individually for offline use, rendering it a valuable resource for the scientific community.<\/jats:p>\n               <jats:p>Database URL: https:\/\/ahp.augusta.edu\/<\/jats:p>","DOI":"10.1093\/database\/baae001","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T13:56:08Z","timestamp":1706536568000},"source":"Crossref","is-referenced-by-count":3,"title":["AHP DB: a reference database of proteins in the human aqueous humor"],"prefix":"10.1093","volume":"2024","author":[{"given":"Tae Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Goyal","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Glass","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Doshi","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Bollinger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lane","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Karthik","family":"Kodeboyina","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"},{"name":"Mass General Brigham , 399 Revolution Drive, Somerville, MA 02145, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Estes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"T\u00f6teberg-Harms","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhi","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"},{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"},{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"},{"name":"Department of Population Health Sciences, Medical College of Georgia, Augusta University , 1120 15th Street, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"2024062912174529600_R1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1874364101004010052","article-title":"Aqueous humor dynamics: a review","volume":"4","author":"Goel","year":"2010","journal-title":"Open Ophthalmol. J."},{"key":"2024062912174529600_R2","volume-title":"Physiology, Aqueous Humor Circulation","author":"Sunderland","year":"2022"},{"key":"2024062912174529600_R3","first-page":"123","article-title":"Diffusion of oxygen in human corneas in vivo","volume":"20","author":"Weissman","year":"1981","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"2024062912174529600_R4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1440-1681.2000.03208.x","article-title":"Formation of the aqueous humor","volume":"27","author":"Macknight","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2024062912174529600_R5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1444-0938.2002.tb02384.x","article-title":"The mechanism of aqueous humour formation","volume":"85","author":"To","year":"2002","journal-title":"Clin. Exp. Optom."},{"key":"2024062912174529600_R6","volume-title":"Intraocular Pressure","author":"Machiele","year":"2022"},{"key":"2024062912174529600_R7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/omi.2015.0029","article-title":"Proteomics of human aqueous humor","volume":"19","author":"Murthy","year":"2015","journal-title":"OMICS"},{"key":"2024062912174529600_R8","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1167\/iovs.10-5531","article-title":"Proteome analysis of human aqueous humor","volume":"51","author":"Chowdhury","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024062912174529600_R9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3109\/02713689009069932","article-title":"Transforming growth factor-\u03b2 in human aqueous humor","volume":"9","author":"Jampel","year":"1990","journal-title":"Curr. Eye Res."},{"key":"2024062912174529600_R10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1255\/ejms.1208","article-title":"Proteins in aqueous humor from cataract patients with and without pseudoexfoliation syndrome","volume":"18","author":"Taube","year":"2012","journal-title":"Eur. J. Mass Spectrom. (Chichester)"},{"key":"2024062912174529600_R11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exer.2012.11.010","article-title":"Quantitative proteomics of aqueous and vitreous fluid from patients with idiopathic epiretinal membranes","volume":"108","author":"Pollreisz","year":"2013","journal-title":"Exp. 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Proteomics"},{"key":"2024062912174529600_R18","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108077","article-title":"The aqueous humor proteome of primary open angle glaucoma: an extensive review","volume":"197","author":"Hubens","year":"2020","journal-title":"Exp. Eye Res."},{"key":"2024062912174529600_R19","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.clinbiochem.2015.08.006","article-title":"Proteomic analysis of aqueous humor proteins associated with cataract development","volume":"48","author":"Ji","year":"2015","journal-title":"Clin. Biochem."},{"key":"2024062912174529600_R20","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1021\/pr300080s","article-title":"Proteomic analysis of the aqueous humor in age-related macular degeneration (AMD) patients","volume":"11","author":"Kim","year":"2012","journal-title":"J. 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