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Enter secreted protein database (SEPDB), an integrated secretory proteomics database offering human, mouse and rat secretory proteomics datasets collected from serum, exosomes and cell culture media. SEPDB compiles secreted protein information from secreted protein database, UniProt and Human Protein Atlas databases to annotate secreted proteomics data based on protein subcellular localization and disease markers. SEPDB integrates the latest predictive modeling techniques to measure deviations in the distribution of signal peptide structures of secreted proteins, extends signal peptide sequence prediction by excluding transmembrane structural domain proteins and updates the validation analysis pipeline for secreted proteins. To establish tissue-specific profiles, we have also created secreted proteomics datasets associated with different human tissues. In addition, we provide information on heterogeneous receptor network organizational relationships, reflective of the complex functional information inherent in the molecular structures of secreted proteins that serve as ligands. Users can take advantage of the Refreshed Search, Analyze, Browse and Download functions of SEPDB, which is available online at https:\/\/sysomics.com\/SEPDB\/.<\/jats:p>\n               <jats:p>Database URL: \u00a0https:\/\/sysomics.com\/SEPDB\/<\/jats:p>","DOI":"10.1093\/database\/baae007","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T14:10:57Z","timestamp":1707747057000},"source":"Crossref","is-referenced-by-count":16,"title":["SEPDB: a database of secreted proteins"],"prefix":"10.1093","volume":"2024","author":[{"given":"Ruiqing","family":"Wang","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College , #5 Dong Dan San Tiao, Beijing 100005, China"},{"name":"Experimental Center, Shandong University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine , #4655 Daxue Road, Changqing District, Jinan, Shandong Province 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , #27 Taiping Road, Haidian District, Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Gao","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College , #5 Dong Dan San Tiao, Beijing 100005, China"},{"name":"Experimental Center, Shandong University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine , #4655 Daxue Road, Changqing District, Jinan, Shandong Province 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , #27 Taiping Road, Haidian District, Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-7922","authenticated-orcid":false,"given":"Xiaochen","family":"Bo","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , #27 Taiping Road, Haidian District, Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Zhu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College , #5 Dong Dan San Tiao, Beijing 100005, China"},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , #96 South Xingdao Ring Road, Haizhu District, Guangzhou 510005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Experimental Center, Shandong University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine , #4655 Daxue Road, Changqing District, Jinan, Shandong Province 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebing","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , #27 Taiping Road, Haidian District, Beijing 100850, 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