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Developed in 2005, its primary goal was to collect structural and functional information into proteins that lack a fixed three-dimensional structure. Today, DisProt has evolved into a major repository that not only collects experimental data but also contributes to our understanding of the IDPs\/IDRs roles in various biological processes, such as autophagy or the life cycle mechanisms in viruses or their involvement in diseases (such as cancer and neurodevelopmental disorders). DisProt offers detailed information on the structural states of IDPs\/IDRs, including state transitions, interactions and their functions, all provided as curated annotations. One of the central activities of DisProt is the meticulous curation of experimental data from the literature. For this reason, to ensure that every expert and volunteer curator possesses the requisite knowledge for data evaluation, collection and integration, training courses and curation materials are available. However, biocuration guidelines concur on the importance of developing robust guidelines that not only provide critical information about data consistency but also ensure data acquisition.This guideline aims to provide both biocurators and external users with best practices for manually curating IDPs and IDRs in DisProt. It describes every step of the literature curation process and provides use cases of IDP curation within DisProt.<\/jats:p>\n               <jats:p>Database URL: https:\/\/disprot.org\/<\/jats:p>","DOI":"10.1093\/database\/baae009","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T14:21:57Z","timestamp":1710944517000},"source":"Crossref","is-referenced-by-count":3,"title":["Best practices for the manual curation of intrinsically disordered proteins in DisProt"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0341-4888","authenticated-orcid":false,"given":"Federica","family":"Quaglia","sequence":"first","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM) , Via Giovanni Amendola, 122\/O, Bari 70126, Italy"},{"name":"Department of Biomedical Sciences, University of Padova , Via Ugo Bassi, 58\/B, Padova 35131, Italy"}]},{"given":"Anastasia","family":"Chasapi","sequence":"additional","affiliation":[{"name":"Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas , 6th km Harilaou - Thermis 57001 Thermi, Thessalonica 57001, Greece"}]},{"given":"Maria Victoria","family":"Nugnes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Via Ugo Bassi, 58\/B, Padova 35131, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-6952","authenticated-orcid":false,"given":"Maria Cristina","family":"Aspromonte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Via Ugo Bassi, 58\/B, Padova 35131, Italy"}]},{"given":"Emanuela","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Via Ugo Bassi, 58\/B, Padova 35131, 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