{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:44:30Z","timestamp":1774680270802,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thailand Major Overseas Programme","award":["106698 2015\u20132020"],"award-info":[{"award-number":["106698 2015\u20132020"]}]},{"DOI":"10.13039\/100019475","name":"Sidra Medicine","doi-asserted-by":"publisher","award":["Internal Research Fund Award"],"award-info":[{"award-number":["Internal Research Fund Award"]}],"id":[{"id":"10.13039\/100019475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thailand Major Overseas Programme","award":["106698 2015\u20132020"],"award-info":[{"award-number":["106698 2015\u20132020"]}]},{"DOI":"10.13039\/100019475","name":"Sidra Medicine","doi-asserted-by":"publisher","award":["Internal Research Fund Award"],"award-info":[{"award-number":["Internal Research Fund Award"]}],"id":[{"id":"10.13039\/100019475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transcriptome profiling data, generated via RNA sequencing, are commonly deposited in public repositories. However, these data may not be easily accessible or usable by many researchers. To enhance data reuse, we present well-annotated, partially analyzed data via a user-friendly web application. This project involved transcriptome profiling of blood samples from 15 healthy pregnant women in a low-resource setting, taken at 6 consecutive time points beginning from the first trimester. Additional blood transcriptome profiles were retrieved from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) public repository, representing a cohort of healthy pregnant women from a high-resource setting. We analyzed these datasets using the fixed BloodGen3 module repertoire. We deployed a web application, accessible at https:\/\/thejacksonlaboratory.shinyapps.io\/BloodGen3_Pregnancy\/which displays the module-level analysis results from both original and public pregnancy blood transcriptome datasets. Users can create custom fingerprint grid and heatmap representations via various navigation options, useful for reports and manuscript preparation. The web application serves as a standalone resource for exploring blood transcript abundance changes during pregnancy. Alternatively, users can integrate it with similar applications developed for earlier publications to analyze transcript abundance changes of a given BloodGen3 signature across a range of disease cohorts.<\/jats:p>\n               <jats:p>Database URL: https:\/\/thejacksonlaboratory.shinyapps.io\/BloodGen3_Pregnancy\/<\/jats:p>","DOI":"10.1093\/database\/baae021","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T18:20:10Z","timestamp":1712082010000},"source":"Crossref","is-referenced-by-count":3,"title":["A data browsing application for accessing gene and module-level blood transcriptome profiles of healthy pregnant women from high- and low-resource settings"],"prefix":"10.1093","volume":"2024","author":[{"given":"Darawan","family":"Rinchai","sequence":"first","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"},{"name":"Department of Infectious Diseases, St Jude\u2019s Children Research Hospital , 262 Danny Thomas Pl, Memphis, TN 38105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Brummaier","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , 78, 1, Mae Ramat 63140, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , New Richards Building, Roosevelt Dr, Oxford OX3 7BN, UK"},{"name":"Swiss Tropical and Public Health Institute , Basel 4123, Switzerland"},{"name":"Faculty of Medicine, University of Basel , Basel 4001, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"A Marr","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-2704","authenticated-orcid":false,"given":"Tanwir","family":"Habib","sequence":"additional","affiliation":[{"name":"Bioinformatics Core, Weill Cornell Medicine-Qatar , Education City, Doha 24144, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Toufiq","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine , 10, Discovery Dr, Farmington, CT 06032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoshigue","family":"Kino","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , 78, 1, Mae Ramat 63140, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , New Richards Building, Roosevelt Dr, Oxford OX3 7BN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souhaila","family":"Al Khodor","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-5373","authenticated-orcid":false,"given":"Annalisa","family":"Terranegra","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1621-3257","authenticated-orcid":false,"given":"Rose","family":"McGready","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , 78, 1, Mae Ramat 63140, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , New Richards Building, Roosevelt Dr, Oxford OX3 7BN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basirudeen Syed Ahamed","family":"Kabeer","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Chaussabel","sequence":"additional","affiliation":[{"name":"Research Branch, Sidra Medicine , Al Gharrafa St, Doha 26999, Qatar"},{"name":"The Jackson Laboratory for Genomic Medicine , 10, Discovery Dr, Farmington, CT 06032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"2024062912212531600_R1","article-title":"Low birthweight as a risk factor for non-communicable diseases in adults","volume":"8","author":"Bianchi","year":"2021","journal-title":"Front. 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