{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:57Z","timestamp":1753876077402,"version":"3.41.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160216 62161033 62361047"],"award-info":[{"award-number":["32160216 62161033 62361047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160216 62161033 62361047"],"award-info":[{"award-number":["32160216 62161033 62361047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The discovery of key epigenetic modifications in cancer is of great significance for the study of disease biomarkers. Through the mining of epigenetic modification data relevant to cancer, some researches on epigenetic modifications are accumulating. In order to make it easier to integrate the effects of key epigenetic modifications on the related cancers, we established CancerMHL (http:\/\/www.positionprediction.cn\/), which provide key DNA methylation, histone modifications and lncRNAs as well as the effect of these key epigenetic modifications on gene expression in several cancers. To facilitate data retrieval, CancerMHL offers flexible query options and filters, allowing users to access specific key epigenetic modifications according to their own needs. In addition, based on the epigenetic modification data, three online prediction tools had been offered in CancerMHL for users. CancerMHL will be a useful resource platform for further exploring novel and potential biomarkers and therapeutic targets in cancer.<\/jats:p>\n               <jats:p>Database URL: http:\/\/www.positionprediction.cn\/<\/jats:p>","DOI":"10.1093\/database\/baae029","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T16:30:27Z","timestamp":1713025827000},"source":"Crossref","is-referenced-by-count":2,"title":["CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer"],"prefix":"10.1093","volume":"2024","author":[{"given":"Pengyu","family":"Du","sequence":"first","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Yingli","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Qianzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Zhimin","family":"Gai","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Hui","family":"Bai","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Luqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Yuxian","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Yanni","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Yuanyuan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]},{"given":"Wen","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University , 235 West Daxue Road, Hohhot 010021, China"}]}],"member":"286","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"2024062912193530300_R1","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1038\/sj.onc.1206774","article-title":"Cancer epigenetics","volume":"22","author":"Momparler","year":"2003","journal-title":"Oncogene"},{"key":"2024062912193530300_R2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrg2005","article-title":"Cancer epigenomics: DNA methylomes and histone-modification maps","volume":"8","author":"Esteller","year":"2007","journal-title":"Nat. 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Genet."},{"key":"2024062912193530300_R6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2009","journal-title":"Carcinogenesis"},{"key":"2024062912193530300_R7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/PPO.0000000000000281","article-title":"Epigenetics and precision oncology","volume":"23","author":"Werner","year":"2017","journal-title":"Cancer J."},{"key":"2024062912193530300_R8","doi-asserted-by":"crossref","first-page":"D1268","DOI":"10.1093\/nar\/gkaa1104","article-title":"MethHC 2.0: information repository of DNA methylation and gene expression in human cancer","volume":"49","author":"Huang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2024062912193530300_R9","doi-asserted-by":"crossref","first-page":"D1208","DOI":"10.1093\/nar\/gkab1088","article-title":"DiseaseMeth version 3.0: a major expansion and update of the human disease 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