{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:51:17Z","timestamp":1783479077283,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":120,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer cell lines are an important component in biological and medical research, enabling studies of cellular mechanisms as well as the development and testing of pharmaceuticals. Genomic alterations in cancer cell lines are widely studied as models for oncogenetic events and are represented in a wide range of primary resources. We have created a comprehensive, curated knowledge resource\u2014cancercelllines.org\u2014with the aim to enable easy access to genomic profiling data in cancer cell lines, curated from a variety of resources and integrating both copy number and single nucleotide variants data. We have gathered over 5600 copy number profiles as well as single nucleotide variant annotations for 16\u2009000 cell lines and provide these data with mappings to the GRCh38 reference genome. Both genomic variations and associated curated metadata can be queried through the GA4GH Beacon v2 Application Programming Interface (API) and a graphical user interface with extensive data retrieval enabled using GA4GH data schemas under a permissive licensing scheme.<\/jats:p>\n                  <jats:p>Database URL: https:\/\/cancercelllines.org<\/jats:p>","DOI":"10.1093\/database\/baae030","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T19:58:56Z","timestamp":1711569536000},"source":"Crossref","is-referenced-by-count":4,"title":["cancercelllines.org\u2014a novel resource for genomic variants in cancer cell lines"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-1689","authenticated-orcid":false,"given":"Rahel","family":"Paloots","sequence":"first","affiliation":[{"name":"Institute of Molecular Life Sciences, University of Zurich , Winterthurerstrasse 190, Zurich 8057, Switzerland"},{"name":"Swiss Institute of Bioinformatics , Winterthurerstrasse 190, Zurich 8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Baudis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Life Sciences, University of Zurich , Winterthurerstrasse 190, Zurich 8057, Switzerland"},{"name":"Swiss Institute of Bioinformatics , Winterthurerstrasse 190, Zurich 8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"2024062912212280000_R1","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1158\/0008-5472.CAN-04-0328","article-title":"Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas","volume":"64","author":"Douglas","year":"2004","journal-title":"Cancer Res."},{"key":"2024062912212280000_R2","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1158\/0008-5472.CAN-07-2864","article-title":"Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome","volume":"68","author":"Camps","year":"2008","journal-title":"Cancer Res."},{"key":"2024062912212280000_R3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-017-0691-y","article-title":"Multi-omics of 34 colorectal cancer cell lines\u2014a resource for biomedical studies","volume":"16","author":"Berg","year":"2017","journal-title":"Mol. 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