{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:57Z","timestamp":1753876077811,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":135,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Research Project (Dengfeng hospital) jointly Funded by Guangzhou City and University","award":["202201020586"],"award-info":[{"award-number":["202201020586"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62003094 and 82003615"],"award-info":[{"award-number":["62003094 and 82003615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects in Guangzhou","award":["202102020573 and 202201010147"],"award-info":[{"award-number":["202102020573 and 202201010147"]}]},{"name":"Basic Research Project (Dengfeng hospital) jointly Funded by Guangzhou City and University","award":["202201020586"],"award-info":[{"award-number":["202201020586"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62003094 and 82003615"],"award-info":[{"award-number":["62003094 and 82003615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects in Guangzhou","award":["202102020573 and 202201010147"],"award-info":[{"award-number":["202102020573 and 202201010147"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Breast cancer is notorious for its high mortality and heterogeneity, resulting in different therapeutic responses. Classical biomarkers have been identified and successfully commercially applied to predict the outcome of breast cancer patients. Accumulating biomarkers, including non-coding RNAs, have been reported as prognostic markers for breast cancer with the development of sequencing techniques. However, there are currently no databases dedicated to the curation and characterization of prognostic markers for breast cancer. Therefore, we constructed a curated database for prognostic markers of breast cancer (PMBC). PMBC consists of 1070 markers covering mRNAs, lncRNAs, miRNAs and circRNAs. These markers are enriched in various cancer- and epithelial-related functions including mitogen-activated protein kinases signaling. We mapped the prognostic markers into the ceRNA network from starBase. The lncRNA NEAT1 competes with 11 RNAs, including lncRNAs and mRNAs. The majority of the ceRNAs in ABAT belong to pseudogenes. The topology analysis of the ceRNA network reveals that known prognostic RNAs have higher closeness than random. Among all the biomarkers, prognostic lncRNAs have a higher degree, while prognostic mRNAs have significantly higher closeness than random RNAs. These results indicate that the lncRNAs play important roles in maintaining the interactions between lncRNAs and their ceRNAs, which might be used as a characteristic to prioritize prognostic lncRNAs based on the ceRNA network. PMBC renders a user-friendly interface and provides detailed information about individual prognostic markers, which will facilitate the precision treatment of breast cancer. PMBC is available at the following URL: http:\/\/www.pmbreastcancer.com\/.<\/jats:p>","DOI":"10.1093\/database\/baae033","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T15:26:00Z","timestamp":1715786760000},"source":"Crossref","is-referenced-by-count":0,"title":["PMBC: a manually curated database for prognostic markers of breast cancer"],"prefix":"10.1093","volume":"2024","author":[{"given":"Jiabei","family":"Liu","sequence":"first","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Yiyi","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Mingyue","family":"Li","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Yixuan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Weijun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Guanru","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Lingxian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Jiechun","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Chujun","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Weijun","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of IoT Information Technology, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Xiaoli","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology , 100 Outer Ring West Road, Guangzhou University City, Panyu District, Guangzhou 510006, China"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024062912213579800_R1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"2024062912213579800_R2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"van \u2018t Veer","year":"2002","journal-title":"Nature"},{"key":"2024062912213579800_R3","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1056\/NEJMoa041588","article-title":"A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer","volume":"351","author":"Paik","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2024062912213579800_R4","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1158\/1078-0432.CCR-11-0926","article-title":"A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors","volume":"17","author":"Filipits","year":"2011","journal-title":"Clin. Cancer. 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