{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:44:04Z","timestamp":1782841444140,"version":"3.54.5"},"reference-count":87,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2019YFA0706202"],"award-info":[{"award-number":["2019YFA0706202"]}]},{"name":"National Key Research and Development Project of China","award":["2019YFA0706202"],"award-info":[{"award-number":["2019YFA0706202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Major depressive disorder (MDD) is a pressing global health issue. Its pathogenesis remains elusive, but numerous studies have revealed its intricate associations with various biological factors. Consequently, there is an urgent need for a comprehensive multi-omics resource to help researchers in conducting multi-omics data analysis for MDD. To address this issue, we constructed the MDDOmics database (Major Depressive Disorder Omics, (https:\/\/www.csuligroup.com\/MDDOmics\/), which integrates an extensive collection of published multi-omics data related to MDD. The database contains 41\u2009222 entries of MDD research results and several original datasets, including Single Nucleotide Polymorphisms, genes, non-coding RNAs, DNA methylations, metabolites and proteins, and offers various interfaces for searching and visualization. We also provide extensive downstream analyses of the collected MDD data, including differential analysis, enrichment analysis and disease-gene prediction. Moreover, the database also incorporates multi-omics data for bipolar disorder, schizophrenia and anxiety disorder, due to the challenge in differentiating MDD from similar psychiatric disorders. In conclusion, by leveraging the rich content and online interfaces from MDDOmics, researchers can conduct more comprehensive analyses of MDD and its similar disorders from various perspectives, thereby gaining a deeper understanding of potential MDD biomarkers and intricate disease pathogenesis.<\/jats:p>\n               <jats:p>Database URL: https:\/\/www.csuligroup.com\/MDDOmics\/<\/jats:p>","DOI":"10.1093\/database\/baae042","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T16:29:47Z","timestamp":1719332987000},"source":"Crossref","is-referenced-by-count":3,"title":["MDDOmics: multi-omics resource of major depressive disorder"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-0865","authenticated-orcid":false,"given":"Yichao","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No.932 South Lushan Road, Changsha 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3045-5706","authenticated-orcid":false,"given":"Ju","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Computer and Communication Engineering, Changsha University of Science and Technology , No.45 Chiling Road, Changsha 410114, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No.932 South Lushan Road, Changsha 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhen","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No.932 South Lushan Road, Changsha 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University , No.139 Renmin Road Central, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-1394","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No.932 South Lushan Road, Changsha 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2024070816482518700_R1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","edition":"5th"},{"key":"2024070816482518700_R2","article-title":"Depressive Disorder (Depression)","author":"World Health Organization","year":"2023"},{"key":"2024070816482518700_R3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0140-6736(07)61415-9","article-title":"Depression, chronic diseases, and decrements in health: results from the World Health Surveys","volume":"370","author":"Moussavi","year":"2007","journal-title":"Lancet"},{"key":"2024070816482518700_R4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators","year":"2017","journal-title":"Lancet"},{"key":"2024070816482518700_R5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(09)60879-5","article-title":"Clinical diagnosis of depression in primary care: a meta-analysis","volume":"374","author":"Mitchell","year":"2009","journal-title":"Lancet"},{"key":"2024070816482518700_R6","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"2024070816482518700_R7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s12264-021-00638-3","article-title":"Major depressive disorder: advances in neuroscience research and translational applications","volume":"37","author":"Li","year":"2021","journal-title":"Neurosci. 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