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The extensive and disparate data on drug transporters complicate understanding their complex relationships with ligands. To address this challenge, it is essential to gather and summarize information on drug transporters, inhibitors and substrates, and simultaneously develop a comprehensive and user-friendly database. Current online resources often provide fragmented information and have limited coverage of drug transporter substrates and inhibitors, highlighting the need for a specialized, comprehensive and openly accessible database. ISTransbase addresses this gap by amassing a substantial amount of data from literature, government documents and open databases. It includes 16\u2009528 inhibitors and 4465 substrates of 163 drug transporters from 18 different species, resulting in a total of 93\u2009841 inhibitor records and 51\u2009053 substrate records. ISTransbase provides detailed insights into drug transporters and their inhibitors\/substrates, encompassing transporter and molecule structure, transporter function and distribution, as well as experimental methods and results from transport or inhibition experiments. Furthermore, ISTransbase offers three search strategies that allow users to retrieve drugs and transporters based on multiple selectable constraints, as well as perform checks for drug\u2013drug interactions. Users can also browse and download data. In summary, ISTransbase (https:\/\/istransbase.scbdd.com\/) serves as a valuable resource for accurately and efficiently accessing information on drug transporter inhibitors and substrates, aiding researchers in exploring drug transporter mechanisms and assisting clinicians in mitigating adverse drug reactions<\/jats:p>\n               <jats:p>Database URL: https:\/\/istransbase.scbdd.com\/<\/jats:p>","DOI":"10.1093\/database\/baae053","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T12:19:29Z","timestamp":1719663569000},"source":"Crossref","is-referenced-by-count":3,"title":["ISTransbase: an online database for inhibitor and substrate of drug transporters"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-2030","authenticated-orcid":false,"given":"Jinfu","family":"Peng","sequence":"first","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , No.172 Tongzipo Road, Changsha, Hunan 410031, China"},{"name":"Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University , No.138 Tongzipo Road, Changsha, Hunan 410031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-1882","authenticated-orcid":false,"given":"Jiacai","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Computer Science, National University of Defense Technology , No.869 Furong Middle Road, Changsha, Hunan 410073, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , No.172 Tongzipo Road, Changsha, Hunan 410031, China"},{"name":"Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University , No.138 Tongzipo Road, Changsha, Hunan 410031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-5212","authenticated-orcid":false,"given":"Zhijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University , No.138 Tongzipo Road, Changsha, Hunan 410031, China"},{"name":"XiangYa School of Medicine, Central South University , No.172 Tongzipo Road, Changsha, Hunan 410031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , No.172 Tongzipo Road, Changsha, Hunan 410031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"2024062912152421100_R1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1021\/acs.chemrestox.5b00511","article-title":"Involvement of drug transporters in organ toxicity: the fundamental basis of drug discovery and development","volume":"29","author":"Cheng","year":"2016","journal-title":"Chem. 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