{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:37:01Z","timestamp":1776181021678,"version":"3.50.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061127 R01AG062634 RF1NS128145"],"award-info":[{"award-number":["R01AG061127 R01AG062634 RF1NS128145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61NS135587"],"award-info":[{"award-number":["R61NS135587"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061127 R01AG062634 RF1NS128145"],"award-info":[{"award-number":["R01AG061127 R01AG062634 RF1NS128145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61NS135587"],"award-info":[{"award-number":["R61NS135587"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development of AD. Given that AD affects more women than men, it is also important to explore DNAm changes that occur specifically in each sex. We created MIAMI-AD, a comprehensive knowledgebase containing manually curated summary statistics from 98 published tables in 38 studies, all of which included at least 100 participants. MIAMI-AD enables easy browsing, querying, and downloading DNAm associations at multiple levels\u2014at individual CpG, gene, genomic regions, or genome-wide, in one or multiple studies. Moreover, it also offers tools to perform integrative analyses, such as comparing DNAm associations across different phenotypes or tissues, as well as interactive visualizations. Using several use case examples, we demonstrated that MIAMI-AD facilitates our understanding of age-associated CpGs in AD and the sex-specific roles of DNAm in AD. This open-access resource is freely available to the research community, and all the underlying data can be downloaded. MIAMI-AD facilitates integrative explorations to better understand the interplay between DNAm across aging, sex, and AD.<\/jats:p>\n                  <jats:p>Database URL: https:\/\/miami-ad.org\/<\/jats:p>","DOI":"10.1093\/database\/baae061","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T17:03:03Z","timestamp":1720026183000},"source":"Crossref","is-referenced-by-count":5,"title":["MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"2024","author":[{"given":"David","family":"Lukacsovich","sequence":"first","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine , 1120 NW 14th Street, Miami, FL 33136, USA"}]},{"given":"Deirdre","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Center for Brain Health, University of Miami, Miller School of Medicine , 7700 W Camino Real, Boca Raton, FL 33433, USA"}]},{"given":"Hanchen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine , 1120 NW 14th Street, Miami, FL 33136, USA"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine , 1120 NW 14th Street, Miami, FL 33136, USA"}]},{"given":"Juan","family":"Young","sequence":"additional","affiliation":[{"name":"Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"}]},{"given":"X Steven","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine , 1120 NW 14th Street, Miami, FL 33136, USA"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , 1475 NW 12th Ave, Miami, FL 33136, USA"}]},{"given":"Sven-Thorsten","family":"Dietrich","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"}]},{"given":"Brian","family":"Kunkle","sequence":"additional","affiliation":[{"name":"Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"}]},{"given":"Eden","family":"Martin","sequence":"additional","affiliation":[{"name":"Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-4251","authenticated-orcid":false,"given":"Lily","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine , 1120 NW 14th Street, Miami, FL 33136, USA"},{"name":"Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine , 1501 NW 10th Ave, Miami, FL 33136, USA"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , 1475 NW 12th Ave, Miami, FL 33136, USA"}]}],"member":"286","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2024072509065020700_R1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer\u2019s disease and mild cognitive impairment in the United States (2020\u20132060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"2024072509065020700_R2","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMsa1204629","article-title":"Monetary costs of dementia in the United States","volume":"368","author":"Hurd","year":"2013","journal-title":"New Engl. J. 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