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Although a large number of SOD1 variants have been reported in ALS patients, the detailed structural properties of each variant are not well summarized. We present SoDCoD, a database of superoxide dismutase conformational diversity, collecting our comprehensive biochemical analyses of the structural changes in SOD1 caused by ALS-linked gene mutations and other perturbations. SoDCoD version 1.0 contains information about the properties of 188 types of SOD1 mutants, including structural changes and their binding to Derlin-1, as well as a set of genes contributing to the proteostasis of mutant-like wild-type SOD1. This database provides valuable insights into the diagnosis and treatment of ALS, particularly by targeting conformational alterations in SOD1.<\/jats:p>\n               <jats:p>Database URL: https:\/\/fujisawagroup.github.io\/SoDCoDweb\/<\/jats:p>","DOI":"10.1093\/database\/baae064","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T04:56:10Z","timestamp":1723265770000},"source":"Crossref","is-referenced-by-count":2,"title":["SoDCoD: a comprehensive database of Cu\/Zn superoxide dismutase conformational diversity caused by ALS-linked gene mutations and other perturbations"],"prefix":"10.1093","volume":"2024","author":[{"given":"Riko","family":"Tabuchi","sequence":"first","affiliation":[{"name":"Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 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