{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:27Z","timestamp":1753875987038,"version":"3.41.2"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":247,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Copper-induced cell death is a novel mechanism of cell death, which is defined as cuproptosis. The increasing level of copper can produce toxicity in cells and may cause the occurrence of cell death. Several previous studies have proved that cuproptosis has a tight association with various cancers. Thus, the discovery of relationships between cuproptosis-related genes (CRGs) and human cancers is of great importance. Pan-cancer analysis can efficiently help researchers find out the relationship between multiple cancers and target genes precisely and make various prognostic analyses on cancers and cancer patients. Pan-cancer web servers can provide researchers with direct results of pan-cancer prognostic analyses, which can greatly improve the efficiency of their work. However, to date, no web server provides pan-cancer analysis about CRGs. Therefore, we introduce the cuproptosis pan-cancer analysis database (CuPCA), the first database for various analysis results of CRGs through 33 cancer types. CuPCA is a user-friendly resource for cancer researchers to gain various prognostic analyses between cuproptosis and cancers. It provides single CRG pan-cancer analysis, multi-CRGs pan-cancer analysis, multi-CRlncRNA pan-cancer analysis, and mRNA\u2013circRNA\u2013lncRNA conjoint analysis. These analysis results can not only indicate the relationship between cancers and cuproptosis at both gene level and protein level, but also predict the conditions of different cancer patients, which include their clinical condition, survival condition, and their immunological condition. CuPCA procures the delivery of analyzed data to end users, which improves the efficiency of wide research as well as releases the value of data resources.<\/jats:p>\n               <jats:p>Database URL: http:\/\/cupca.cn\/<\/jats:p>","DOI":"10.1093\/database\/baae075","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:44:33Z","timestamp":1725533073000},"source":"Crossref","is-referenced-by-count":0,"title":["CuPCA: a web server for pan-cancer association analysis of large-scale cuproptosis-related genes"],"prefix":"10.1093","volume":"2024","author":[{"given":"Yishu","family":"Xu","sequence":"first","affiliation":[{"name":"College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenshu","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Beijing Forestry University , Beijing 100083,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University , Beijing 100015,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Art, Beijing Forestry University , Beijing 100083,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3167-9151","authenticated-orcid":false,"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University , Beijing 100015,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-0675","authenticated-orcid":false,"given":"Zhengrong","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"2024100511561210200_R1","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1007\/s11427-022-2106-6","article-title":"Cuproptosis: copper-induced regulated cell death","volume":"65","author":"Duan","year":"2022","journal-title":"Sci China Life Sci"},{"key":"2024100511561210200_R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114830","article-title":"The molecular mechanisms of cuproptosis and its relevance to 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