{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:49:33Z","timestamp":1772837373268,"version":"3.50.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":240,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2018R1A5A1025077 2021R1I1A1A01056588 2022M3A9B6082687"],"award-info":[{"award-number":["2018R1A5A1025077 2021R1I1A1A01056588 2022M3A9B6082687"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2018R1A5A1025077 2021R1I1A1A01056588 2022M3A9B6082687"],"award-info":[{"award-number":["2018R1A5A1025077 2021R1I1A1A01056588 2022M3A9B6082687"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoinhibition, a crucial allosteric self-regulation mechanism in cell signaling, ensures signal propagation exclusively in the presence of specific molecular inputs. The heightened focus on autoinhibited proteins stems from their implication in human diseases, positioning them as potential causal factors or therapeutic targets. However, the absence of a comprehensive knowledgebase impedes a thorough understanding of their roles and applications in drug discovery. Addressing this gap, we introduce Autoinhibited Protein Database (AiPD), a curated database standardizing information on autoinhibited proteins. AiPD encompasses details on autoinhibitory domains (AIDs), their targets, regulatory mechanisms, experimental validation methods, and implications in diseases, including associated mutations and post-translational modifications. AiPD comprises 698 AIDs from 532 experimentally characterized autoinhibited proteins and 2695 AIDs from their 2096 homologs, which were retrieved from 864 published articles. AiPD also includes 42\u2009520 AIDs of computationally predicted autoinhibited proteins. In addition, AiPD facilitates users in investigating potential AIDs within a query sequence through comparisons with documented autoinhibited proteins. As the inaugural autoinhibited protein repository, AiPD significantly aids researchers studying autoinhibition mechanisms and their alterations in human diseases. It is equally valuable for developing computational models, analyzing allosteric protein regulation, predicting new drug targets, and understanding intervention mechanisms AiPD serves as a valuable resource for diverse researchers, contributing to the understanding and manipulation of autoinhibition in cellular processes.<\/jats:p>\n               <jats:p>Database URL: http:\/\/ssbio.cau.ac.kr\/databases\/AiPD.<\/jats:p>","DOI":"10.1093\/database\/baae085","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T04:03:48Z","timestamp":1724817828000},"source":"Crossref","is-referenced-by-count":2,"title":["Autoinhibited Protein Database: a curated database of autoinhibitory domains and their autoinhibition mechanisms"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7229-3952","authenticated-orcid":false,"given":"Daeahn","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Hyang-Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Ji Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Jae Gwang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"given":"Su-hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Bomi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"given":"Jinsil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"given":"Kha Mong","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Jiwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"given":"Phuong Ngoc Lam","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Jooeun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"given":"Teerapat","family":"Pimt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]},{"given":"Kangseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chung-Ang University , Seoul 06974, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-6594","authenticated-orcid":false,"given":"J\u00f6rg","family":"Gsponer","sequence":"additional","affiliation":[{"name":"Center for High-Throughput Biology, University of British Columbia , 2125 East Mall, Vancouver, BC V6T 1Z4, Canada"}]},{"given":"Hyung Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-7040","authenticated-orcid":false,"given":"Dokyun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University , Seoul 06974, South Korea"}]}],"member":"286","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"2024082804032004000_R1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.cellbio.18.031502.133614","article-title":"Autoinhibitory domains: modular effectors of cellular regulation","volume":"18","author":"Pufall","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2024082804032004000_R2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nsmb.1428","article-title":"Internal dynamics control activation and activity of the autoinhibited Vav DH domain","volume":"15","author":"Li","year":"2008","journal-title":"Nat Struct Mol 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