{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:54:19Z","timestamp":1782471259336,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":352,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2022NSFSC0779"],"award-info":[{"award-number":["2022NSFSC0779"]}]},{"name":"Basic Research Cultivation Support Program of Fundamental Research Funds for the Central Universities","award":["2682023ZTPY071"],"award-info":[{"award-number":["2682023ZTPY071"]}]},{"name":"Key research and development project of Sichuan Science and Technology Department","award":["24ZDYF0889"],"award-info":[{"award-number":["24ZDYF0889"]}]},{"name":"Sichuan Science and Technology Program","award":["2022NSFSC0779"],"award-info":[{"award-number":["2022NSFSC0779"]}]},{"name":"Basic Research Cultivation Support Program of Fundamental Research Funds for the Central Universities","award":["2682023ZTPY071"],"award-info":[{"award-number":["2682023ZTPY071"]}]},{"name":"Key research and development project of Sichuan Science and Technology Department","award":["24ZDYF0889"],"award-info":[{"award-number":["24ZDYF0889"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extrachromosomal circular DNA (eccDNA), an extrachromosomal circular structured DNA, is extensively found in eukaryotes. Investigating eccDNA at the single-cell level is crucial for understanding cellular heterogeneity, evolution, development, and specific cellular functions. However, high-throughput identification methods for single-cell eccDNA are complex, and the lack of mature, widely applicable technologies has resulted in limited resources. To address this gap, we built scEccDNAdb, a database based on single-cell whole-genome sequencing data. It contains 3\u2009195\u2009464 single-cell eccDNA entries from human and mouse samples, with annotations including oncogenes, typical enhancers, super-enhancers, CCCTC-binding factor-binding sites, single nucleotide polymorphisms, chromatin accessibility, expression quantitative trait loci, transcription factor binding sites, motifs, and structural variants. Additionally, it provides nine online analysis and visualization tools, which enable the creation of publication-quality figures through user-uploaded files. Overall, scEccDNAdb is a comprehensive database for analyzing single-cell eccDNA data across diverse cell types, tissues, and species.<\/jats:p>\n                  <jats:p>Database URL: https:\/\/lcbb.swjtu.edu.cn\/scEccDNAdb\/<\/jats:p>","DOI":"10.1093\/database\/baae126","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T23:20:30Z","timestamp":1733095230000},"source":"Crossref","is-referenced-by-count":2,"title":["scEccDNAdb: an integrated single-cell eccDNA resource for human and mouse"],"prefix":"10.1093","volume":"2024","author":[{"given":"Wenqing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-5924","authenticated-orcid":false,"given":"Tengwei","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnuo","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-785X","authenticated-orcid":false,"given":"Zhiyun","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , No.111, North 1st Section of Second Ring Road, Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"2025030818073236800_R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107680","article-title":"Methods, bioinformatics tools and databases in ecDNA research: an overview","volume":"167","author":"Zhao","year":"2023","journal-title":"Comput Biol 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