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Currently, hundreds of guidelines exist, each applicable to a particular clinical domain. However, they are scattered across multiple resources and scientific literature. To address this issue, we present VarGuideAtlas, a comprehensive repository of variant interpretation guidelines that compiles information from ClinGen, ClinVar, and PubMed. Our repository offers a user-friendly web interface with advanced search capabilities, enabling clinicians and researchers to efficiently find relevant guidelines tailored to specific genes, diseases, or variant types. We employ ontologies to characterize each guideline, ensuring consistency and improving interoperability with bioinformatics tools. VarGuideAtlas represents a significant advance toward standardizing variant interpretation practices, facilitating more informed decision-making, improved clinical outcomes, and more precise genomic research. VarGuideAtlas is publicly accessible via a web-based platform (https:\/\/genomics-hub.pros.dsic.upv.es:3016\/).<\/jats:p>","DOI":"10.1093\/database\/baaf017","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:03:32Z","timestamp":1741694612000},"source":"Crossref","is-referenced-by-count":1,"title":["VarGuideAtlas: a repository of variant interpretation guidelines"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-0914","authenticated-orcid":false,"given":"Mireia","family":"Costa","sequence":"first","affiliation":[{"name":"PROS Research Center, VRAIN, Universitat Polit\u00e8cnica de Val\u00e8ncia , Cami de Vera, S\/N, Valencia, Valencia 46022,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-4363","authenticated-orcid":false,"given":"Alberto","family":"Garc\u00eda S.","sequence":"additional","affiliation":[{"name":"PROS Research Center, VRAIN, Universitat Polit\u00e8cnica de Val\u00e8ncia , Cami de Vera, S\/N, Valencia, Valencia 46022,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-6115","authenticated-orcid":false,"given":"Oscar","family":"Pastor","sequence":"additional","affiliation":[{"name":"PROS Research Center, VRAIN, Universitat Polit\u00e8cnica de Val\u00e8ncia , Cami de Vera, S\/N, Valencia, Valencia 46022,","place":["Spain"]}]}],"member":"286","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"2025092510515312800_R1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2431","article-title":"Next-generation sequencing","volume":"11","author":"Reis-Filho","year":"2009","journal-title":"Breast Cancer Res"},{"key":"2025092510515312800_R2","doi-asserted-by":"publisher","DOI":"10.1002\/cphg.93","article-title":"Overview of specifications to the ACMG\/AMP variant interpretation guidelines","volume":"103","author":"Harrison","year":"2019","journal-title":"Curr Protoc Hum Genet"},{"key":"2025092510515312800_R3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2025092510515312800_R4","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/s41436-018-0432-7","article-title":"A survey assessing adoption of the ACMG-AMP guidelines for interpreting sequence variants and identification of areas for continued improvement","volume":"21","author":"Niehaus","year":"2019","journal-title":"Genet Med"},{"key":"2025092510515312800_R5","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.5.421","article-title":"Challenges and considerations in sequence variant interpretation for Mendelian disorders","volume":"39","author":"Kim","year":"2019","journal-title":"Ann Lab Med"},{"key":"2025092510515312800_R6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13012-018-0763-4","article-title":"The advantages and limitations of guideline adaptation frameworks","volume":"13","author":"Wang","year":"2018","journal-title":"Implement Sci"},{"article-title":"Criteria Specification Registry","year":"2024","author":"ClinGen","key":"2025092510515312800_R7"},{"key":"2025092510515312800_R8","doi-asserted-by":"publisher","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","article-title":"ClinVar: public archive of relationships among sequence variation and human phenotype","volume":"42","author":"Landrum","year":"2014","journal-title":"Nucleic Acids Res"},{"article-title":"Ontology Lookup Service","year":"2024","author":"E. 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