{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T06:24:13Z","timestamp":1766298253282,"version":"3.44.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":226,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2021-1058"],"award-info":[{"award-number":["075-15-2021-1058"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pregnancy loss is an important reproductive health problem that affects many couples. Genetic factors play an important role in both spontaneous miscarriage and recurrent pregnancy loss, and the effect of genomic variants is recognized as one of the major causes of pregnancy loss in euploid foetuses. In this work, we extend our previous analysis of the genetic landscape of pregnancy loss and develop a Pregnancy Loss genetic Variant (PLoV) database to aggregate information about mutations that have been implicated in pregnancy loss. The database contains information about 534 genetic variants that have been observed in 421 cases across 47 studies, including foetus-only, parent-only, and trio-based studies. For each case, the database includes a detailed description of the phenotype, including ultrasound data (if provided in the original article). The genetic variants are scattered across all chromosomes in the human genome and affect a total of 292 unique genes. We provide a public access to the PLoV database at https:\/\/plovdb.ott.ru\/.<\/jats:p>\n               <jats:p>Database URL: https:\/\/plovdb.ott.ru\/<\/jats:p>","DOI":"10.1093\/database\/baaf037","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:22:51Z","timestamp":1751948571000},"source":"Crossref","is-referenced-by-count":1,"title":["PLoV: a comprehensive database of genetic variants leading to pregnancy loss"],"prefix":"10.1093","volume":"2025","author":[{"given":"Evgeniia M","family":"Maksiutenko","sequence":"first","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology Department of Genomic Medicine, , Mendeleevskaya line, 3, Saint Petersburg, 199034 ,","place":["Russia"]}]},{"given":"Igor V","family":"Bezdvornykh","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology Department of Genomic Medicine, , Mendeleevskaya line, 3, Saint Petersburg, 199034 ,","place":["Russia"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-440X","authenticated-orcid":false,"given":"Yury A","family":"Barbitoff","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology Department of Genomic Medicine, , Mendeleevskaya line, 3, Saint Petersburg, 199034 ,","place":["Russia"]}]},{"given":"Yulia A","family":"Nasykhova","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology Department of Genomic Medicine, , Mendeleevskaya line, 3, Saint Petersburg, 199034 ,","place":["Russia"]}]},{"given":"Andrey S","family":"Glotov","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology Department of Genomic Medicine, , Mendeleevskaya line, 3, Saint Petersburg, 199034 ,","place":["Russia"]}]}],"member":"286","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"2025092510270575200_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4103\/jhrs.JHRS_140_18","article-title":"Causes and prevalence of factors causing infertility in a public health facility","volume":"12","author":"Deshpande","year":"2019","journal-title":"J Hum Reprod Sci"},{"key":"2025092510270575200_bib2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10815-017-1108-y","article-title":"Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss","volume":"35","author":"Arias-Sosa","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2025092510270575200_bib3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/aogs.14523","article-title":"Pregnancy complications and later life women\u2019s health","volume":"102","author":"McNestry","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2025092510270575200_bib4","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3390\/jcm12051827","article-title":"Prevention of pregnancy loss: combining progestogen treatment and psychological support","volume":"12","author":"Tetruashvili","year":"2023","journal-title":"J Clin Med"},{"key":"2025092510270575200_bib5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2147\/IJWH.S100817","article-title":"Recurrent pregnancy loss: current perspectives","volume":"9","author":"El\u00a0Hachem","year":"2017","journal-title":"Int J Womens Health"},{"key":"2025092510270575200_bib6","first-page":"247","article-title":"WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976","volume":"56","year":"1977","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2025092510270575200_bib7","doi-asserted-by":"publisher","first-page":"4074","DOI":"10.3390\/jcm12124074","article-title":"2023 Recurrent pregnancy loss etiology, risk factors, diagnosis, and management. Fresh look into a full box","volume":"12","author":"Turesheva","year":"2023","journal-title":"J Clin Med"},{"key":"2025092510270575200_bib8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1097\/01.AOG.0000137350.89939.2a","article-title":"Poor obstetric outcome in subsequent pregnancies in women with prior fetal death","volume":"104","author":"Frias","year":"2004","journal-title":"Obstet Gynecol"},{"key":"2025092510270575200_bib9","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.2174\/092986710793176302","article-title":"Genetic factors as a cause of miscarriage","volume":"17","author":"Suzumori","year":"2010","journal-title":"Curr Med Chem"},{"key":"2025092510270575200_bib10","first-page":"570","article-title":"Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management","volume":"2","author":"Cao","year":"2022","journal-title":"Med Rev 2021"},{"key":"2025092510270575200_bib11","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41591-022-02142-1","article-title":"Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death","volume":"29","author":"Byrne","year":"2023","journal-title":"Nat Med"},{"key":"2025092510270575200_bib12","doi-asserted-by":"publisher","first-page":"770517","DOI":"10.3389\/frph.2021.770517","article-title":"A systematic review to guide future efforts in the determination of genetic causes of pregnancy loss","volume":"3","author":"Carey","year":"2021","journal-title":"Front Reprod Health"},{"key":"2025092510270575200_bib13","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s10815-019-01499-6","article-title":"Genetic diagnosis in first or second trimester pregnancy loss using exome sequencing: a systematic review of human essential genes","volume":"36","author":"Robbins","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2025092510270575200_bib14","doi-asserted-by":"publisher","first-page":"17572","DOI":"10.3390\/ijms242417572","article-title":"The landscape of point mutations in human protein coding genes leading to pregnancy loss","volume":"24","author":"Maksiutenko","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025092510270575200_bib15","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"2025092510270575200_bib16","first-page":"405","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med Off J Am Coll Med Genet"},{"key":"2025092510270575200_bib17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/jmg.2011.089144","article-title":"NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage","volume":"48","author":"Messaed","year":"2011","journal-title":"J Med Genet"},{"key":"2025092510270575200_bib18","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/imr.13289","article-title":"FOXP3 deficiency, from the mechanisms of the disease to curative strategies","volume":"322","author":"Borna","year":"2024","journal-title":"Immunol Rev"},{"key":"2025092510270575200_bib19","doi-asserted-by":"publisher","first-page":"bbad508","DOI":"10.1093\/bib\/bbad508","article-title":"Bioinformatics of germline variant discovery for rare disease diagnostics: current approaches and remaining challenges","volume":"25","author":"Barbitoff","year":"2024","journal-title":"Brief Bioinform"},{"key":"2025092510270575200_bib20","doi-asserted-by":"publisher","first-page":"D1062","DOI":"10.1093\/nar\/gkx1153","article-title":"ClinVar: improving access to variant interpretations and supporting evidence","volume":"46","author":"Landrum","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2025092510270575200_bib21","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s00439-020-02199-3","article-title":"The Human Gene Mutation Database (HGMD\u00ae): optimizing its use in a clinical diagnostic or research setting","volume":"139","author":"Stenson","year":"2020","journal-title":"Hum Genet"}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaf037\/64062118\/baaf037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaf037\/64062118\/baaf037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:27:16Z","timestamp":1758810436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baaf037\/8191733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1093\/database\/baaf037","relation":{},"ISSN":["1758-0463"],"issn-type":[{"type":"electronic","value":"1758-0463"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"baaf037"}}