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Livestock such as cattle and sheep are critical reservoirs for zoonotic pathogens and play a key role in transmitting these pathogens to humans and other animals, including dogs and wildlife, due to their close interaction with diverse populations. In this study, we introduce Zoonosis (http:\/\/zoonosis.cn\/zoonosis\/), a comprehensive database that integrates data on pathogens, including Brucella, Mycobacterium tuberculosis, and Bacillus anthracis. Currently, Zoonosis integrates over 4500 samples from more than 60 countries, with a total data volume of 1.8TB, providing a global perspective on zoonotic disease distribution. Equipped with user-friendly visualization and analysis tools, Zoonosis enables rapid biological data interpretation, aiding disease diagnosis and prevention. This resource supports virology, zoology, and epidemiology experts in monitoring cross-species transmissions and mitigating future zoonotic outbreaks.<\/jats:p>\n               <jats:p>Database URL: http:\/\/zoonosis.cn\/zoonosis\/<\/jats:p>","DOI":"10.1093\/database\/baaf062","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:38:26Z","timestamp":1760557106000},"source":"Crossref","is-referenced-by-count":0,"title":["Zoonosis: a comprehensive database of zoonotic pathogens"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6685-9383","authenticated-orcid":false,"given":"Boyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences , No. 2 Yuanmingyuan West Road, Beijing 100193 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