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The database simplifies the complex workflows associated with spaceflight-related biology studies by combining curated molecular lists, transcriptomic datasets from NASA\u2019s GeneLab, and user-uploaded data into a streamlined, user-friendly interface. H-SPAR DB enables researchers to perform differential expression analysis, set operations, and association analyses while also generating integrative knowledge graphs around a space-related biological theme. The platform reduces the time required for data gathering and processing by offering a single platform for data exploration, analysis, and visualization. By integrating interactive visualizations and data tables, H-SPAR DB facilitates the interpretation of results, ultimately enhancing the efficiency of space biology research and fostering discoveries that address human health challenges in space. Researchers can access H-SPAR DB freely at https:\/\/bioinformatics.cing.ac.cy\/H-SPARDB\/ without login or other requirements.<\/jats:p>","DOI":"10.1093\/database\/baaf083","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:07:05Z","timestamp":1765544825000},"source":"Crossref","is-referenced-by-count":0,"title":["H-SPAR DB: human spaceflight platform for analysis and research\u2014an integrative omics database for space health"],"prefix":"10.1093","volume":"2026","author":[{"given":"Marios","family":"Tomazou","sequence":"first","affiliation":[{"name":"Bioinformatics Department, The Cyprus Institute of Neurology and Genetics , 2371 Nicosia ,","place":["Cyprus"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-0634","authenticated-orcid":false,"given":"Marilena M","family":"Bourdakou","sequence":"additional","affiliation":[{"name":"Bioinformatics Department, The Cyprus Institute of Neurology and Genetics , 2371 Nicosia 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