{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:58:51Z","timestamp":1776369531040,"version":"3.51.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":100,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brown University Computing and Information Services"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rapid progress in tumour genome sequencing has created a need for bioinformatics tools to interpret the clinical significance of detected variants. VarStack\u00b2 integrates information from several publicly available resources, including the Catalogue of Somatic Mutations in Cancer (COSMIC), ClinVar, cBioPortal, UCSC Genome Browser, and ClinicalTrials.gov, CIViC and presents it through a user-friendly interface. VarStack2 simplifies the process of retrieving data, saving users significant time compared to manually navigating each database individually. Users can input a variant by specifying a gene symbol, amino acid change, and coding sequence change, with the option to search tumour-specific studies in cBioPortal alongside their primary query. Results are organized into separate sections and can be exported in CSV format for further analysis. Additionally, VarStack2 offers a smart search feature that suggests variants for the gene of interest based on its database search results. These features make VarStack2 a useful tool for scientists and clinicians by enhancing the variant interpretation process and integrating somatic variant information into workflows. VarStack\u00b2 is freely available at http:\/\/varstack.brown.edu\/<\/jats:p>","DOI":"10.1093\/database\/baag016","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:38:32Z","timestamp":1774096712000},"source":"Crossref","is-referenced-by-count":0,"title":["VarStack2\u2014an interactive web tool for somatic variant interpretation in cancer"],"prefix":"10.1093","volume":"2026","author":[{"given":"Nitin","family":"Sreekumar","sequence":"first","affiliation":[{"name":"The Warren Alpert Medical School of Brown University Department of Pathology and Laboratory Medicine, , 593 Eddy Street, Providence, RI 02903 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J","family":"Ahn","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University , 222 Richmond Street, Providence, RI 02912 ,","place":["United 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