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Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8\u2009519\u2009425 single cells from single-cell RNA-seq studies and 140\u2009744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer\u2019s disease, Parkinson\u2019s disease, schizophrenia, bipolar disorder, and multiple sclerosis. BDCD reconstructs more than 495\u2009000 ligand\u2013receptor interaction events and links them to structural features, genetic associations, pathways, and therapeutic modulators, including 6100 single nucleotide polymorphisms from genome-wide association studies, 3350 drugs, and 72\u2009477 allosteric modulators. This comprehensive atlas enables cross-disease comparison and supports dynamic hypothesis generation, providing a foundation for mechanistic insights and therapeutic discovery. BDCD is publicly available at https:\/\/bioinfo.uth.edu\/bdcd\/. Database URL: https:\/\/bioinfo.uth.edu\/bdcd\/<\/jats:p>","DOI":"10.1093\/database\/baag017","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:38:27Z","timestamp":1774096707000},"source":"Crossref","is-referenced-by-count":0,"title":["BDCD: a comprehensive Brain Disease Cell-cell communication Database"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-1004","authenticated-orcid":false,"given":"Xinyi","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Citu","family":"Citu","sequence":"additional","affiliation":[{"name":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , 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