{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:00:29Z","timestamp":1773406829705,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":2102,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"DOI":"10.1093\/database\/bar047","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T00:13:55Z","timestamp":1319501635000},"source":"Crossref","is-referenced-by-count":5,"title":["Critical amino acid residues in proteins: a BioMart integration of Reactome protein annotations with PRIDE mass spectrometry data and COSMIC somatic mutations"],"prefix":"10.1093","volume":"2011","author":[{"given":"Nelson","family":"Ndegwa","sequence":"first","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"},{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ovelleiro","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"D'Eustachio","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Vizca\u00edno","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Croft","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Life Science, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK and 3New York University School of Medicine, Department of Biochemistry, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,10,22]]},"reference":[{"key":"key\n\t\t\t\t20180618195541_bar047-B1","first-page":"119","article-title":"Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing","volume":"13","author":"Campbell","year":"2002","journal-title":"J. Biomol. Tech."},{"key":"key\n\t\t\t\t20180618195541_bar047-B2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1074\/mcp.M500135-MCP200","article-title":"Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements","volume":"5","author":"Steen","year":"2006","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20180618195541_bar047-B3","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1002\/pmic.201000244","article-title":"Organelle proteomics experimental designs and analysis","volume":"10","author":"Gatto","year":"2010","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180618195541_bar047-B4","doi-asserted-by":"crossref","first-page":"D736","DOI":"10.1093\/nar\/gkp964","article-title":"The Proteomics Identifications database: 2010 update","volume":"38","author":"Vizcaino","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B5","doi-asserted-by":"crossref","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","article-title":"Reactome: a database of reactions, pathways and biological processes","volume":"39","author":"Croft","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B6","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkq929","article-title":"COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer","volume":"39","author":"Forbes","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B7","doi-asserted-by":"crossref","first-page":"W23","DOI":"10.1093\/nar\/gkp265","article-title":"BioMart Central Portal\u2013unified access to biological data","volume":"37","author":"Haider","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B8","doi-asserted-by":"crossref","first-page":"D563","DOI":"10.1093\/nar\/gkp871","article-title":"Ensembl genomes: extending Ensembl across the taxonomic space","volume":"38","author":"Kersey","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B9","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bar009","article-title":"UniProt knowledgebase: a hub of integrated protein data","author":"Magrane","year":"2011","journal-title":"Database"},{"key":"key\n\t\t\t\t20180618195541_bar047-B10","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bar031","article-title":"The Reactome BioMart","author":"Haw","year":"2011","journal-title":"Database"},{"key":"key\n\t\t\t\t20180618195541_bar047-B11","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bar018","article-title":"Data mining using the Catalogue of Somatic Mutations in Cancer BioMart","author":"Shepherd","year":"2011","journal-title":"Database"},{"key":"key\n\t\t\t\t20180618195541_bar047-B12","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nbt0808-864","article-title":"The PSI-MOD community standard for representation of protein modification data","volume":"26","author":"Montecchi-Palazzi","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180618195541_bar047-B13","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/pmic.200300777","article-title":"The RESID Database of Protein Modifications as a resource and annotation tool","volume":"4","author":"Garavelli","year":"2004","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180618195541_bar047-B14","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/pmic.200300744","article-title":"Unimod: protein modifications for mass spectrometry","volume":"4","author":"Creasy","year":"2004","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180618195541_bar047-B15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ceb.2007.02.007","article-title":"Wnt\/beta-catenin signaling in cancer stemness and malignant behavior","volume":"19","author":"Fodde","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20180618195541_bar047-B16","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1101\/gad.1324905","article-title":"Defining the impact of beta-catenin\/Tcf transactivation on epithelial stem cells","volume":"19","author":"Lowry","year":"2004","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180618195541_bar047-B17","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1242\/jcs.02532","article-title":"On mammary stem cells","volume":"118","author":"Woodward","year":"2005","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20180618195541_bar047-B18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","article-title":"A role for Wnt signalling in self-renewal of haematopoietic stem cells","volume":"423","author":"Reya","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618195541_bar047-B19","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1101\/gad.230302","article-title":"Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway","volume":"16","author":"Amit","year":"2002","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180618195541_bar047-B20","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1038\/sj.onc.1210059","article-title":"Colorectal cancer and genetic alterations in the Wnt pathway","volume":"25","author":"Segditsas","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180618195541_bar047-B21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1517\/14728222.11.1.91","article-title":"The Src signaling pathway: a potential target in melanoma and other malignancies","volume":"11","author":"Homsi","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"key\n\t\t\t\t20180618195541_bar047-B22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/5971","article-title":"Activating SRC mutation in a subset of advanced human colon cancers","volume":"21","author":"Irby","year":"1999","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180618195541_bar047-B23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1098\/rstb.1998.0228","article-title":"The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease","volume":"353","author":"Hunter","year":"1998","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"key\n\t\t\t\t20180618195541_bar047-B24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1349-7006.2000.tb00958.x","article-title":"Mutation of the SRC gene in endometrial carcinoma","volume":"91","author":"Sugimura","year":"2000","journal-title":"Jpn. J. Cancer Res."},{"key":"key\n\t\t\t\t20180618195541_bar047-B25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/cb900277e","article-title":"Phosphoproteomics for the masses","volume":"5","author":"Grimsrud","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"key\n\t\t\t\t20180618195541_bar047-B26","first-page":"302","article-title":"Shotgun proteomics: integrating technologies to answer biological questions","volume":"5","author":"McDonald","year":"2003","journal-title":"Curr. Opin. Mol. Ther."},{"key":"key\n\t\t\t\t20180618195541_bar047-B27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry","volume":"4","author":"Elias","year":"2007","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180618195541_bar047-B28","doi-asserted-by":"crossref","first-page":"pe8","DOI":"10.1126\/scisignal.2001813","article-title":"The potential cost of high-throughput proteomics","volume":"4","author":"White","year":"2011","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20180618195541_bar047-B29","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nbt1240","article-title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization","volume":"24","author":"Beausoleil","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180618195541_bar047-B30","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.4161\/cc.9.7.11066","article-title":"Roles of \"junk phosphorylation\" in modulating biomolecular association of phosphorylated proteins?","volume":"9","author":"Tan","year":"2010","journal-title":"Cell Cycle"}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/bar047\/14094979\/bar047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T14:25:57Z","timestamp":1560867957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/bar047\/468739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1093\/database\/bar047","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011]]},"published":{"date-parts":[[2011,1,1]]}}}