{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:54:05Z","timestamp":1768546445726,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":1737,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1093\/database\/bas006","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T16:30:25Z","timestamp":1332433825000},"source":"Crossref","is-referenced-by-count":62,"title":["Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments"],"prefix":"10.1093","volume":"2012","author":[{"given":"Jose","family":"Cruz-Toledo","sequence":"first","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Maureen","family":"McKeague","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Xueru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Amanda","family":"Giamberardino","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Erin","family":"McConnell","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Tariq","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Maria C.","family":"DeRosa","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"},{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]},{"given":"Michel","family":"Dumontier","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"},{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"},{"name":"Department of Biology, Carleton University, 2Department of Chemistry, Carleton University, 3Institute of Biochemistry, Department of Biology and Department Chemistry, Carleton University and 4School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6"}]}],"member":"286","published-online":{"date-parts":[[2012,2,13]]},"reference":[{"key":"key\n\t\t\t\t20180618191550_bas006-B1","doi-asserted-by":"crossref","DOI":"10.1002\/3527601813","volume-title":"Protein-Ligand Interactions: From Molecular Recognition to Drug Design","author":"B\u00f6hm","year":"2003"},{"key":"key\n\t\t\t\t20180618191550_bas006-B2","doi-asserted-by":"crossref","DOI":"10.1002\/0471142700.nc0901s00","article-title":"Theoretical principles of in vitro selection using combinatorial nucleic acid libraries","author":"Vant-Hull","year":"2000","journal-title":"Curr. Protoc. Nucleic Acid Chem."},{"key":"key\n\t\t\t\t20180618191550_bas006-B3","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2174\/138920111796117436","article-title":"Advances in methods for therapeutic peptide discovery, design and development","volume":"12","author":"Pirogova","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/molecules16010790","article-title":"Phage display: selecting straws instead of a needle from a haystack","volume":"16","author":"Vodnik","year":"2011","journal-title":"Molecules"},{"key":"key\n\t\t\t\t20180618191550_bas006-B5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nbt.1791","article-title":"Beyond natural antibodies: the power of in vitro display technologies","volume":"29","author":"Bradbury","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.sbi.2011.03.015","article-title":"Computational approaches to RNA structure prediction, analysis, and design","volume":"21","author":"Laing","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s13238-010-0065-3","article-title":"The next-generation sequencing technology and application","volume":"1","author":"Zhou","year":"2010","journal-title":"Protein Cell"},{"key":"key\n\t\t\t\t20180618191550_bas006-B8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nbt1360","article-title":"The minimum information about a genome sequence (MIGS) specification","volume":"26","author":"Field","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B9","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/455590b","article-title":"Don't forget people and specimens that make the database","volume":"455","author":"Campbell","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618191550_bas006-B10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2105-9-121","article-title":"SciDBMaker: new software for computer-aided design of specialized biological databases","volume":"9","author":"Hammami","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180618191550_bas006-B11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","article-title":"In vitro selection of RNA molecules that bind specific ligands","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618191550_bas006-B12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.2200121","article-title":"Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase","volume":"249","author":"Tuerk","year":"1990","journal-title":"Science"},{"key":"key\n\t\t\t\t20180618191550_bas006-B13","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/clinchem\/45.9.1628","article-title":"Aptamers: an emerging class of molecules that rival antibodies in diagnostics","volume":"45","author":"Jayasena","year":"1999","journal-title":"Clin. Chem."},{"key":"key\n\t\t\t\t20180618191550_bas006-B14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nchembio.369","article-title":"Reprogramming bacteria to seek and destroy an herbicide","volume":"6","author":"Sinha","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B15","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/ac902226v","article-title":"An RNA-aptamer-based assay for the detection and analysis of malachite green and leucomalachite green residues in fish tissue","volume":"82","author":"Stead","year":"2010","journal-title":"Anal. Chem."},{"key":"key\n\t\t\t\t20180618191550_bas006-B16","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.3390\/ijms11124864","article-title":"Screening and initial binding assessment of fumonisin b(1) aptamers","volume":"11","author":"McKeague","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"key\n\t\t\t\t20180618191550_bas006-B17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2011.08.027","article-title":"An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells","volume":"313","author":"Kim","year":"2011","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20180618191550_bas006-B18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1128\/JVI.02626-09","article-title":"RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production","volume":"85","author":"Ramalingam","year":"2011","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1021\/cn100114k","article-title":"In vitro selection of DNA aptamers to glioblastoma multiforme","volume":"2","author":"Bayrac","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"key\n\t\t\t\t20180618191550_bas006-B20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev.med.56.062904.144915","article-title":"Aptamers: an emerging class of therapeutics","volume":"56","author":"Nimjee","year":"2005","journal-title":"Annu. Rev. Med."},{"key":"key\n\t\t\t\t20180618191550_bas006-B21","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI11325","article-title":"Developing aptamers into therapeutics","volume":"106","author":"White","year":"2000","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20180618191550_bas006-B22","first-page":"5","article-title":"Aptamers as therapeutic and diagnostic agents","volume":"74","author":"Brody","year":"2000","journal-title":"J. Biotechnol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B23","doi-asserted-by":"crossref","DOI":"10.5772\/22350","article-title":"Advances in Aptamer-Based Biosensors for Food Safety","volume-title":"Environmental BioSensors","author":"McKeague","year":"2011"},{"key":"key\n\t\t\t\t20180618191550_bas006-B24","doi-asserted-by":"crossref","first-page":"D95","DOI":"10.1093\/nar\/gkh094","article-title":"Aptamer database","volume":"32","author":"Lee","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618191550_bas006-B25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/nar\/30.1.195","article-title":"SELEX_DB: a database on in vitro selected oligomers adapted for recognizing natural sites and for analyzing both SNPs and site-directed mutagenesis data","volume":"30","author":"Ponomarenko","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618191550_bas006-B26","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2105-7-S2-S6","article-title":"RiboaptDB: a comprehensive database of ribozymes and aptamers","volume":"7","author":"Thodima","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180618191550_bas006-B27","doi-asserted-by":"crossref","first-page":"D32","DOI":"10.1093\/nar\/gkq1079","article-title":"GenBank","volume":"39","author":"Benson","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618191550_bas006-B28","doi-asserted-by":"crossref","first-page":"D19","DOI":"10.1093\/nar\/gkn765","article-title":"Petabyte-scale innovations at the European Nucleotide Archive","volume":"37","author":"Cochrane","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618191550_bas006-B29","doi-asserted-by":"crossref","first-page":"D33","DOI":"10.1093\/nar\/gkp847","article-title":"DDBJ launches a new archive database with analytical tools for next-generation sequence data","volume":"38","author":"Kaminuma","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618191550_bas006-B30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1145\/320434.320440","article-title":"The entity-relationship model\u2014toward a unified view of data","volume":"1","author":"Chen","year":"1976","journal-title":"ACM Transactions on database systems"},{"key":"key\n\t\t\t\t20180618191550_bas006-B31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-0-387-73711-9_3","article-title":"Artificial functional nucleic acids: aptamers, ribozymes, and deoxyribozymes identified by in vitro selection","volume-title":"Functional Nucleic Acids for Analytical Applications","author":"Silverman","year":"2009"},{"key":"key\n\t\t\t\t20180618191550_bas006-B32","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/bioinformatics\/btl023","article-title":"Memory efficient folding algorithms for circular RNA secondary structures","volume":"22","author":"Hofacker","year":"2006","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180618191550_bas006-B33","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1073\/pnas.0401799101","article-title":"Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure","volume":"101","author":"Mathews","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180618191550_bas006-B34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.2700","article-title":"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure","volume":"288","author":"Mathews","year":"1999","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180618191550_bas006-B35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06684","article-title":"The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data","volume":"452","author":"Parisien","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618191550_bas006-B36","author":"SweoIG\/TaskForces\/CommunityProjects\/LinkingOpenData","year":"2011"},{"key":"key\n\t\t\t\t20180618191550_bas006-B37","author":"RDF Primer","year":"2004"},{"key":"key\n\t\t\t\t20180618191550_bas006-B38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.anchem.1.031207.112851","article-title":"Applications of aptamers as sensors","volume":"2","author":"Cho","year":"2009","journal-title":"Annu. Rev. Anal. Chem. (Palo Alto Calif)"},{"key":"key\n\t\t\t\t20180618191550_bas006-B39","doi-asserted-by":"crossref","first-page":"D249","DOI":"10.1093\/nar\/gkp886","article-title":"Chemical entities of biological interest: an update","volume":"38","author":"de Matos","year":"2010","journal-title":"Nucleic Acids Res."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/bas006\/16728609\/bas006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T15:17:41Z","timestamp":1593875861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/bas006\/431883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1093\/database\/bas006","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012]]},"published":{"date-parts":[[2012,1,1]]}}}