{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:48:22Z","timestamp":1791298102203,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":676,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"DOI":"10.1093\/database\/bav035","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:32:00Z","timestamp":1428625920000},"source":"Crossref","is-referenced-by-count":78,"title":["miRGate: a curated database of human, mouse and rat miRNA\u2013mRNA targets"],"prefix":"10.1093","volume":"2015","author":[{"given":"Eduardo","family":"Andr\u00e9s-Le\u00f3n","sequence":"first","affiliation":[{"name":"Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and 2 High Technical School of Computer Engineering, University of Vigo, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gonz\u00e1lez Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and 2 High Technical School of Computer Engineering, University of Vigo, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"G\u00f3mez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and 2 High Technical School of Computer Engineering, University of Vigo, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pisano","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and 2 High Technical School of Computer Engineering, University of Vigo, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"key\n\t\t\t\t20180618203347_bav035-B1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20180618203347_bav035-B2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature08139","article-title":"MicroRNA-mediated switching of chromatin-remodelling complexes in neural development","volume":"460","author":"Yoo","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618203347_bav035-B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618203347_bav035-B4","first-page":"83","article-title":"MicroRNAs: processing, maturation, target recognition and regulatory functions","volume":"3","author":"Shukla","year":"2011","journal-title":"Mol. Cell. Pharmacol."},{"key":"key\n\t\t\t\t20180618203347_bav035-B5","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1261\/rna.032284.112","article-title":"Kinetic signatures of microRNA modes of action","volume":"18","author":"Morozova","year":"2012","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180618203347_bav035-B6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/dna.2006.0545","article-title":"Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny","volume":"26","author":"Lee","year":"2007","journal-title":"DNA Cell Biol."},{"key":"key\n\t\t\t\t20180618203347_bav035-B7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tree.2008.06.005","article-title":"Origins and evolution of eukaryotic RNA interference","volume":"23","author":"Shabalina","year":"2008","journal-title":"Trends Ecol. Evol."},{"key":"key\n\t\t\t\t20180618203347_bav035-B8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618203347_bav035-B9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180618203347_bav035-B10","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180618203347_bav035-B11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/CMAR.S7280","article-title":"Epigenomics in cancer management","volume":"2","author":"Costa","year":"2010","journal-title":"Cancer Manag. Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2202-10-98","article-title":"Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis","volume":"10","author":"Nielsen","year":"2009","journal-title":"BMC Neurosci."},{"key":"key\n\t\t\t\t20180618203347_bav035-B13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","article-title":"MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure","volume":"116","author":"Thum","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180618203347_bav035-B14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180618203347_bav035-B15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2105-8-69","article-title":"Inference of miRNA targets using evolutionary conservation and pathway analysis","volume":"8","author":"Gaidatzis","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180618203347_bav035-B16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180618203347_bav035-B17","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1126\/science.1121158","article-title":"The widespread impact of mammalian MicroRNAs on mRNA repression and evolution","volume":"310","author":"Farh","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20180618203347_bav035-B18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3858\/emm.2010.42.4.032","article-title":"Got target? Computational methods for microRNA target prediction and their extension","volume":"42","author":"Min","year":"2010","journal-title":"Exp. Mol. Med."},{"key":"key\n\t\t\t\t20180618203347_bav035-B19","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1093\/bioinformatics\/btq589","article-title":"MiRonTop: mining microRNAs targets across large scale gene expression studies","volume":"26","author":"Le Brigand","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180618203347_bav035-B20","doi-asserted-by":"crossref","first-page":"D252","DOI":"10.1093\/nar\/gks1168","article-title":"MiRGator v3.0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting","volume":"41","author":"Cho","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2014database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J. Biomed. Inform."},{"key":"key\n\t\t\t\t20180618203347_bav035-B22","doi-asserted-by":"crossref","first-page":"W13","DOI":"10.1093\/nar\/gks460","article-title":"MAGIA(2): from miRNA and genes expression data integrative analysis to microRNA-transcription factor mixed regulatory circuits (2012 update)","volume":"40","author":"Bisognin","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B23","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkp294","article-title":"MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression","volume":"37","author":"Nam","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nmeth0609-397","article-title":"Predicting microRNA targets and functions: traps for the unwary","volume":"6","author":"Ritchie","year":"2009","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180618203347_bav035-B25","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B26","doi-asserted-by":"crossref","first-page":"D749","DOI":"10.1093\/nar\/gkt1196","article-title":"Ensembl 2014","volume":"42","author":"Flicek","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B27","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nature09144","article-title":"A coding-independent function of gene and pseudogene mRNAs regulates tumour biology","volume":"465","author":"Poliseno","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618203347_bav035-B28","doi-asserted-by":"crossref","first-page":"D110","DOI":"10.1093\/nar\/gks1058","article-title":"APPRIS: annotation of principal and alternative splice isoforms","volume":"41","author":"Rodriguez","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B29","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for the ENCODE project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B30","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1186\/gb-2012-13-9-r51","article-title":"The GENCODE pseudogene resource","volume":"13","author":"Pei","year":"2012","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180618203347_bav035-B31","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180618203347_bav035-B32","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180618203347_bav035-B33","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","author":"Kruger","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B34","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1186\/1471-2105-7-S5-S20","article-title":"MicroTar: predicting microRNA targets from RNA duplexes","volume":"7","author":"Thadani","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180618203347_bav035-B35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B36","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1101\/gr.3715005","article-title":"Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes","volume":"15","author":"Siepel","year":"2005","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B37","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkr1161","article-title":"TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support","volume":"40","author":"Vergoulis","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B38","doi-asserted-by":"crossref","first-page":"D78","DOI":"10.1093\/nar\/gkt1266","article-title":"miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions","volume":"42","author":"Hsu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B39","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.1093\/nar\/gkn851","article-title":"miRecords: an integrated resource for microRNA-target interactions","volume":"37","author":"Xiao","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180618203347_bav035-B40","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/bioinformatics\/btu155","article-title":"OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs","volume":"30","author":"Wang","year":"2014","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180618203347_bav035-B41","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ajhg.2011.03.004","article-title":"Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel","volume":"88","author":"Gonzalez-Perez","year":"2011","journal-title":"Am J. Hum. Genet"},{"key":"key\n\t\t\t\t20180618203347_bav035-B42","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in R","volume":"21","author":"Sing","year":"2005","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180618203347_bav035-B43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10549-011-1905-4","article-title":"Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFkappaB pathway","volume":"134","author":"Tanic","year":"2012","journal-title":"Breast Cancer Res. Treat"},{"key":"key\n\t\t\t\t20180618203347_bav035-B44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/leu.2011.189","article-title":"Epstein-Barr virus microRNAs repress BCL6 expression in diffuse large B-cell lymphoma","volume":"26","author":"Martin-Perez","year":"2012","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20180618203347_bav035-B45","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1038\/bjc.2013.612","article-title":"MicroRNA-based molecular classification of non-BRCA1\/2 hereditary breast tumours","volume":"109","author":"Tanic","year":"2013","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20180618203347_bav035-B46","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1182\/blood-2010-10-315432","article-title":"Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway","volume":"117","author":"Bueno","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180618203347_bav035-B47","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/leu.2012.302","article-title":"Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype","volume":"27","author":"Rio-Machin","year":"2013","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20180618203347_bav035-B48","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/leu.2010.91","article-title":"Mantle cell lymphoma: transcriptional regulation by microRNAs","volume":"24","author":"Di Lisio","year":"2010","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20180618203347_bav035-B49","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1038\/bcj.2012.1","article-title":"MicroRNA signatures in B-cell lymphomas","volume":"2","author":"Di Lisio","year":"2012","journal-title":"Blood Cancer J."},{"key":"key\n\t\t\t\t20180618203347_bav035-B50","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-9378-9-12","article-title":"The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma","volume":"9","author":"Ambrosio","year":"2014","journal-title":"Infect. Agent. Cancer"},{"key":"key\n\t\t\t\t20180618203347_bav035-B51","first-page":"1","article-title":"APADB: a database for alternative polyadenylation and microRNA regulation events","author":"Muller","year":"2014","journal-title":"Database"},{"key":"key\n\t\t\t\t20180618203347_bav035-B52","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1145\/337180.337228","article-title":"Principled design of the modern web architecture","volume-title":"Proceedings of the 22nd International Conference on Software Engineering","author":"Fielding","year":"2000"},{"key":"key\n\t\t\t\t20180618203347_bav035-B53","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180618203347_bav035-B54","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1155390","article-title":"Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites","volume":"320","author":"Sandberg","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20180618203347_bav035-B55","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1007\/s00018-012-0990-9","article-title":"Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements","volume":"69","author":"Barrett","year":"2012","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/bav035\/16976027\/bav035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T09:50:31Z","timestamp":1691574631000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/bav035\/2433167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1093\/database\/bav035","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015]]},"published":{"date-parts":[[2015,1,1]]}}}