{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:00:48Z","timestamp":1775062848596,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":348,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["xx2014009"],"award-info":[{"award-number":["xx2014009"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Immunosuppression is body\u2019s state in which the activation or efficacy of immune system is weakened. It is associated with a wide spectrum of human diseases. In the last two decades, tremendous efforts have been made to elucidate the mechanism of hundreds of immunosuppression genes. Immunosuppression genes could be valuable drug targets or biomarkers for the immunotherapeutic treatment of different diseases. However, the information of all previously identified immunosuppression genes is dispersed in thousands of publications. Here, we provide the HisgAtlas database that collects 995 previously identified human immunosuppression genes using text mining and manual curation. We believe HisgAtlas will be a valuable resource to search human immunosuppression genes as well as to investigate their functions in further research.<\/jats:p>\n               <jats:p>Database URL: http:\/\/biokb.ncpsb.org\/HisgAtlas\/<\/jats:p>","DOI":"10.1093\/database\/bax094","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T12:08:39Z","timestamp":1511438919000},"source":"Crossref","is-referenced-by-count":41,"title":["HisgAtlas 1.0: a human immunosuppression gene database"],"prefix":"10.1093","volume":"2017","author":[{"given":"Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Mengqi","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Lihong","family":"Diao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Jinying","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}]},{"given":"Li","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Shuzhen","family":"Guo","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}]},{"given":"Fuchu","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]},{"given":"Dong","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China"}]}],"member":"286","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"2020053110300531200_bax094-B1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1256864","article-title":"Teaching the immune system \u2018self\u2019 respect and tolerance","volume":"344","author":"Chatenoud","year":"2014","journal-title":"Science"},{"key":"2020053110300531200_bax094-B2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. 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