{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:36:33Z","timestamp":1775889393759,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Thousand Talents Program","award":["KJ 2070000026"],"award-info":[{"award-number":["KJ 2070000026"]}]},{"name":"CAS-TWAS President\u2019s Fellowship"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91540107"],"award-info":[{"award-number":["91540107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In recent years, researches focusing on PIWI-interacting RNAs (piRNAs) have increased rapidly. It has been revealed that piRNAs have strong association with a wide range of diseases; thus, it becomes very important to understand piRNAs\u2019 role(s) in disease diagnosis, prognosis and assessment of treatment response. We searched more than 2500 articles using keywords, such as `PIWI-interacting RNAs\u2019 and `piRNAs\u2019, and further scrutinized the articles to collect piRNAs-disease association data. These data are highly complex and heterogeneous due to various types of piRNA idnetifiers (IDs) and different reference genome versions. We put considerable efforts into removing redundancy and anomalies and thus homogenized the data. Finally, we developed the piRDisease database, which incorporates experimentally supported data for piRNAs\u2019 relationship with wide range of diseases. The piRDisease (piRDisease v1.0) is a novel, comprehensive and exclusive database resource, which provides 7939 manually curated associations of experimentally supported 4796 piRNAs involved in 28 diseases. piRDisease facilitates users by providing detailed information of the piRNA in respective disease, explored by experimental support, brief description, sequence and location information. Considering piRNAs\u2019 role(s) in wide range of diseases, it is anticipated that huge amount of data would be produced in the near future. We thus offer a submitting page, on which users or researches can contribute in to update our piRDisease database.<\/jats:p>","DOI":"10.1093\/database\/baz052","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T07:12:18Z","timestamp":1554534738000},"source":"Crossref","is-referenced-by-count":53,"title":["piRDisease v1.0: a manually curated database for piRNA associated diseases"],"prefix":"10.1093","volume":"2019","author":[{"given":"Azhar","family":"Muhammad","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China"},{"name":"Department of Biosciences, COMSATS University Islamabad, Sahiwal 57000, Pakistan"}]},{"given":"Ramay","family":"Waheed","sequence":"additional","affiliation":[{"name":"Pattern Recognition and Information Retrieval lab, University of Science and Technology Beijing, Beijing 100083, China"}]},{"given":"Nauman Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Wireless Optical Communication, Chinese Academy of Sciences, University of Science and Technology China, Hefei 230026, China"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China"}]},{"given":"Xiaoyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China"}]}],"member":"286","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"2019070300124546800_ref1","first-page":"405","article-title":"PIWI-interacting RNA: its biogenesis and functions","volume-title":"Annu. 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