{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:20:04Z","timestamp":1770272404242,"version":"3.49.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":156,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/database\/baz060","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T19:11:42Z","timestamp":1556133102000},"source":"Crossref","is-referenced-by-count":14,"title":["ResMarkerDB: a database of biomarkers of response to antibody therapy in breast and colorectal cancer"],"prefix":"10.1093","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-3000","authenticated-orcid":false,"given":"Judith","family":"P\u00e9rez-Granado","sequence":"first","affiliation":[{"name":"Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Medical Research Institute), UPF (Pompeu Fabra University), Dr. Aiguader, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-7654","authenticated-orcid":false,"given":"Janet","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Medical Research Institute), UPF (Pompeu Fabra University), Dr. Aiguader, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-528X","authenticated-orcid":false,"given":"Laura I","family":"Furlong","sequence":"additional","affiliation":[{"name":"Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Medical Research Institute), UPF (Pompeu Fabra University), Dr. Aiguader, Barcelona, Spain"}]}],"member":"286","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"2019060602352050700_ref1","first-page":"12","article-title":"Beyond molecular tumor heterogeneity: protein synthesis takes control","volume":"37","author":"Ramon Cajal","year":"2018","journal-title":"Oncogene"},{"key":"2019060602352050700_ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12929-016-0311-y","article-title":"State of the art in anti-cancer mAbs","volume":"24","author":"Chiavenna","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"2019060602352050700_ref3","author":"International Agency for Research on Cancer","year":"2012"},{"key":"2019060602352050700_ref4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/CCO.0000000000000330","article-title":"Biomarkers for the identification of recurrence in human epidermal growth factor receptor 2-positive breast cancer patients","volume":"28","author":"Pruneri","year":"2016","journal-title":"Curr. Opin. Oncol."},{"key":"2019060602352050700_ref5","doi-asserted-by":"crossref","first-page":"24781","DOI":"10.18632\/oncotarget.4959","article-title":"New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?","volume":"6","author":"Bronte","year":"2015","journal-title":"Oncotarget"},{"key":"2019060602352050700_ref6","first-page":"63","article-title":"Evaluating biomarkers for guiding treatment decisions","volume":"26","author":"Bossuyt","year":"2015","journal-title":"EJIFCC"},{"key":"2019060602352050700_ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13073-018-0531-8","article-title":"Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations","volume":"10","author":"Tamborero","year":"2018","journal-title":"Genome Med."},{"key":"2019060602352050700_ref8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.3774","article-title":"CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer","volume":"49","author":"Griffith","year":"2017","journal-title":"Nat. Genet."},{"key":"2019060602352050700_ref9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40246-016-0061-7","article-title":"The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies","volume":"10","author":"Patterson","year":"2016","journal-title":"Hum. Genomics"},{"key":"2019060602352050700_ref10","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1093\/bioinformatics\/btx523","article-title":"ncDR: a comprehensive resource of non-coding RNAs involved in drug resistance","volume":"33","author":"Dai","year":"2017","journal-title":"Bioinformatics"},{"key":"2019060602352050700_ref11","doi-asserted-by":"crossref","first-page":"W518","DOI":"10.1093\/nar\/gkt441","article-title":"PubTator: a web-based text mining tool for assisting biocuration","volume":"41","author":"Wei","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6947-12-148","article-title":"Mining biomarker information in biomedical literature","volume":"12","author":"Younesi","year":"2012","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"2019060602352050700_ref13","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref14","doi-asserted-by":"crossref","first-page":"D7","DOI":"10.1093\/nar\/gkv1290","article-title":"Database resources of the National Center for Biotechnology Information","volume":"44","author":"NCBI Resource Coordinators,N.R","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref15","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref16","article-title":"ATC classification index with DDDs, 2018","author":"WHO Collaborating Centre for Drug Statistics Methodology","year":"2017"},{"key":"2019060602352050700_ref17","first-page":"118","volume-title":"Proceedings of the 8th International Conference on Semantic Web Applications and Tools for Life Sciences","author":"Jupp","year":"2015"},{"key":"2019060602352050700_ref18","doi-asserted-by":"crossref","first-page":"D267","DOI":"10.1093\/nar\/gkh061","article-title":"The Unified Medical Language System (UMLS): integrating biomedical terminology","volume":"32","author":"Bodenreider","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref19","doi-asserted-by":"crossref","first-page":"D1071","DOI":"10.1093\/nar\/gku1011","article-title":"Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data","volume":"43","author":"Kibbe","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref20","author":"Django Software Foundation","year":"2017"},{"key":"2019060602352050700_ref21","doi-asserted-by":"crossref","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","article-title":"PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements","volume":"45","author":"Mi","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ccell.2018.03.014","article-title":"A comprehensive pan-cancer molecular study of gynecologic and breast cancers","volume":"33","author":"Berger","year":"2018","journal-title":"Cancer Cell"},{"key":"2019060602352050700_ref23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Network","year":"2012","journal-title":"Nature"},{"key":"2019060602352050700_ref24","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1093\/nar\/gkv1507","article-title":"an R\/Bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref25","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res."},{"key":"2019060602352050700_ref26","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019060602352050700_ref27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"2019060602352050700_ref28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive characterization of cancer driver genes and mutations","volume":"173","author":"Bailey","year":"2018","journal-title":"Cell"},{"key":"2019060602352050700_ref29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3390\/ijms18040752","article-title":"Recent advances in targeting the EGFR signaling pathway for the treatment of metastatic colorectal cancer","volume":"18","author":"Miyamoto","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2019060602352050700_ref30","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1158\/1078-0432.CCR-13-1070","article-title":"Phase Ib study of buparlisib plus trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on trastuzumab-based therapy","volume":"20","author":"Saura","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"2019060602352050700_ref31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/2159-8290.CD-12-0362","article-title":"Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives","volume":"3","author":"Dieci","year":"2013","journal-title":"Cancer Discov."},{"key":"2019060602352050700_ref32","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1158\/1078-0432.CCR-15-2499","article-title":"Relationship between tumor biomarkers and efficacy in EMILIA, a phase III study of trastuzumab emtansine in HER2-positive metastatic breast cancer","volume":"22","author":"Baselga","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"2019060602352050700_ref33","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1158\/1078-0432.CCR-16-2191","article-title":"HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer","volume":"23","author":"Xu","year":"2017","journal-title":"Clin. Cancer Res."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baz060\/28762485\/baz060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T06:35:35Z","timestamp":1559802935000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baz060\/5510694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1093\/database\/baz060","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019]]},"published":{"date-parts":[[2019,1,1]]},"article-number":"baz060"}}