{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:53:22Z","timestamp":1782896002643,"version":"3.54.5"},"reference-count":70,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU\/EFPIA Innovative Medicines Initiative Joint Undertaking","award":["115568"],"award-info":[{"award-number":["115568"]}]},{"name":"Fraunhofer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/database\/baz068","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T15:10:58Z","timestamp":1556723458000},"source":"Crossref","is-referenced-by-count":30,"title":["Re-curation and rational enrichment of knowledge graphs in Biological Expression Language"],"prefix":"10.1093","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4423-4370","authenticated-orcid":false,"given":"Charles Tapley","family":"Hoyt","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"},{"name":"Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-6145","authenticated-orcid":false,"given":"Daniel","family":"Domingo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"},{"name":"Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-9970","authenticated-orcid":false,"given":"Rana","family":"Aldisi","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"},{"name":"Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-8616","authenticated-orcid":false,"given":"Lingling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"},{"name":"Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-5277","authenticated-orcid":false,"given":"Kristian","family":"Kolpeja","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-4413","authenticated-orcid":false,"given":"Sandra","family":"Spalek","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-929X","authenticated-orcid":false,"given":"Esther","family":"Wollert","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-2466","authenticated-orcid":false,"given":"John","family":"Bachman","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Ave, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9439-5346","authenticated-orcid":false,"given":"Benjamin M","family":"Gyori","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Ave, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-0608","authenticated-orcid":false,"given":"Patrick","family":"Greene","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Ave, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9012-6720","authenticated-orcid":false,"given":"Martin","family":"Hofmann-Apitius","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany"},{"name":"Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"2019062104100219800_ref1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/bioinformatics\/btg015","article-title":"The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models","volume":"19","author":"Hucka","year":"2003","journal-title":"Bioinformatics"},{"key":"2019062104100219800_ref2","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/nbt1210-1308c","article-title":"The BioPAX community standard for pathway data sharing","volume":"28","author":"Demir","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"2019062104100219800_ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.drudis.2013.12.011","article-title":"Recent advances in modeling languages for pathway maps and computable biological networks","volume":"19","author":"Slater","year":"2014","journal-title":"Drug Discov. Today"},{"key":"2019062104100219800_ref4","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources: the gene ontology consortium","volume":"45","author":"Carbon","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref5","doi-asserted-by":"crossref","first-page":"D1248","DOI":"10.1093\/nar\/gkx1023","article-title":"BioModels: expanding horizons to include more modelling approaches and formats","volume":"46","author":"Glont","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/nar\/gkq1039","article-title":"Pathway Commons, a web resource for biological pathway data","volume":"39","author":"Cerami","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cels.2015.10.001","article-title":"NDEx, the Network Data Exchange","volume":"1","author":"Pratt","year":"2015","journal-title":"Cell Systems"},{"key":"2019062104100219800_ref8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jbi.2008.03.004","article-title":"Bio2RDF: towards a mashup to build bioinformatics knowledge systems","volume":"41","author":"Belleau","year":"2008","journal-title":"J. Biomed. Inform."},{"key":"2019062104100219800_ref9","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.drudis.2012.05.016","article-title":"Open PHACTS: semantic interoperability for drug discovery","volume":"17","author":"Williams","year":"2012","journal-title":"Drug Discov. Today"},{"key":"2019062104100219800_ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bay126","article-title":"BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language","volume":"2018","author":"Hoyt","year":"2018","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00521-014-1617-x","article-title":"Computational models for inferring biochemical networks","volume":"26","author":"Rausanu","year":"2015","journal-title":"Neural Comput. Appl."},{"key":"2019062104100219800_ref12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tibtech.2015.12.013","article-title":"Trans-omics: how to reconstruct biochemical networks across multiple \u2018omic\u2019 layers","volume":"34","author":"Yugi","year":"2016","journal-title":"Trends Biotechnol."},{"key":"2019062104100219800_ref13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.csbj.2015.03.009","article-title":"KENeV: a web-application for the automated reconstruction and visualization of the enriched metabolic and signaling super-pathways deriving from genomic experiments","volume":"13","author":"Pilalis","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"2019062104100219800_ref14","doi-asserted-by":"crossref","first-page":"W552","DOI":"10.1093\/nar\/gkv399","article-title":"Pathways with PathWhiz","volume":"43","author":"Pon","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12918-015-0181-z","article-title":"The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms","volume":"9","author":"Tripathi","year":"2015","journal-title":"BMC Syst. Biol."},{"key":"2019062104100219800_ref16","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1186\/gb-2010-11-1-r3","article-title":"NetPath: a public resource of curated signal transduction pathways","volume":"11","author":"Kandasamy","year":"2010","journal-title":"Genome Biol."},{"key":"2019062104100219800_ref17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/nar\/gks1055","article-title":"The ConsensusPathDB interaction database: 2013 update","volume":"41","author":"Kamburov","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref18","doi-asserted-by":"crossref","first-page":"D471","DOI":"10.1093\/nar\/gkv1164","article-title":"The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway\/genome databases","volume":"44","author":"Caspi","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref19","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1109\/JPROC.2015.2483592","article-title":"A review of relational machine learning for knowledge graphs","volume":"104","author":"Nickel","year":"2016","journal-title":"Proc. IEEE"},{"key":"2019062104100219800_ref21","first-page":"1","volume-title":"CEUR Workshop Proceedings","author":"Mihindukulasooriya","year":"2017"},{"key":"2019062104100219800_ref22","first-page":"1752","volume-title":"Conference on Empirical Methods in Natural Language Processing","author":"Pujara","year":"2017"},{"key":"2019062104100219800_ref23","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nmeth.3963","article-title":"Impact of outdated gene annotations on pathway enrichment analysis","volume":"13","author":"Wadi","year":"2016","journal-title":"Nat. Methods"},{"key":"2019062104100219800_ref24","doi-asserted-by":"crossref","first-page":"29179","DOI":"10.3390\/ijms161226148","article-title":"Bioinformatics mining and modeling methods for the identification of disease mechanisms in neurodegenerative disorders","volume":"16","author":"Hofmann-Apitius","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2019062104100219800_ref25","first-page":"bby025","article-title":"Navigating the disease landscape: knowledge representations for contextualizing molecular signatures","author":"Saqi","year":"2018","journal-title":"Brief. Bioinform."},{"key":"2019062104100219800_ref26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1752-0509-1-58","article-title":"MIRIAM Resources: tools to generate and resolve robust cross-references in Systems Biology","volume":"1","author":"Laibe","year":"2007","journal-title":"BMC Syst. Biol."},{"key":"2019062104100219800_ref27","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/nar\/gkr1097","article-title":"Identifiers.org and MIRIAM Registry: community resources to provide persistent identification","volume":"40","author":"Juty","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-7-97","article-title":"The Ontology Lookup Service, a lightweight cross-platform tool for controlled vocabulary queries","volume":"7","author":"Cote","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"2019062104100219800_ref29","first-page":"103","volume-title":"Lecture Notes in Computer Science","author":"Gon\u00e7alves","year":"2017"},{"key":"2019062104100219800_ref30","first-page":"3","article-title":"ComPath: an ecosystem for exploring, analyzing, and curating pathway databases","volume":"5","author":"Domingo-Fern\u00e1ndez","year":"2018","journal-title":"NPJ Syst. Biol. Appl."},{"key":"2019062104100219800_ref31","first-page":"243","article-title":"PathMe: merging and exploring mechanistic pathway knowledge","volume-title":"BMC Bioinformatics","author":"Domingo-Fern\u00e1ndez","year":"2019"},{"key":"2019062104100219800_ref32","doi-asserted-by":"crossref","first-page":"D479","DOI":"10.1093\/nar\/gku975","article-title":"The complex portal\u2014an encyclopaedia of macromolecular complexes","volume":"43","author":"Meldal","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref33","doi-asserted-by":"crossref","first-page":"D548","DOI":"10.1093\/nar\/gkv1048","article-title":"SIGNOR: a database of causal relationships between biological entities","volume":"44","author":"Perfetto","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/baw136","article-title":"The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track","volume":"2016","author":"Madan","year":"2016","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4939-7027-8_2","article-title":"sbv IMPROVER: modern approach to systems biology","volume":"1613","author":"Guryanova","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"2019062104100219800_ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bav116","article-title":"Biocuration with insufficient resources and fixed timelines","volume":"2015","author":"Rodriguez-Esteban","year":"2015","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref37","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1093\/bioinformatics\/btx399","article-title":"Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment","volume":"33","author":"Domingo-Fern\u00e1ndez","year":"2017","journal-title":"Bioinformatics"},{"key":"2019062104100219800_ref38","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/bioinformatics\/btx660","article-title":"PyBEL: a computational framework for Biological Expression Language","volume":"34","author":"Hoyt","year":"2018","journal-title":"Bioinformatics"},{"key":"2019062104100219800_ref39","author":"Hoyt","year":"2018"},{"key":"2019062104100219800_ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/737168","article-title":"Computational modelling approaches on epigenetic factors in neurodegenerative and autoimmune diseases and their mechanistic analysis","volume":"2015","author":"Irin","year":"2015","journal-title":"J. Immunol. Res."},{"key":"2019062104100219800_ref41","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jalz.2015.02.006","article-title":"Computable cause-and-effect models of healthy and Alzheimer\u2019s disease states and their mechanistic differential analysis","volume":"11","author":"Kodamullil","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2019062104100219800_ref42","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/bib\/bbv063","article-title":"Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases","volume":"17","author":"Naz","year":"2016","journal-title":"Brief. Bioinform."},{"key":"2019062104100219800_ref43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3233\/JAD-160222","article-title":"Using drugs as molecular probes: a computational chemical biology approach in neurodegenerative diseases","volume":"56","author":"Emon","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"2019062104100219800_ref44","doi-asserted-by":"crossref","first-page":"269860","DOI":"10.1093\/database\/bay050","article-title":"A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities","volume":"2018","author":"Hoyt","year":"2018","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref45","doi-asserted-by":"crossref","first-page":"D619","DOI":"10.1093\/nar\/gkw1033","article-title":"Genenames.org: the HGNC and VGNC resources in 2017","volume":"45","author":"Yates","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref46","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/nar\/gks1146","article-title":"The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013","volume":"41","author":"Hastings","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref47","first-page":"114","article-title":"Medical subject headings","volume":"51","author":"Rogers","year":"1963","journal-title":"Bull. Med. Libr. Assoc."},{"key":"2019062104100219800_ref48","doi-asserted-by":"crossref","first-page":"D955","DOI":"10.1093\/nar\/gky1032","article-title":"Human Disease Ontology 2018 update: classification, content and workflow expansion","volume":"47","author":"Schriml","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref49","first-page":"1","article-title":"Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources","author":"K\u00f6hler","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2041-1480-5-37","article-title":"CLO: the cell line ontology","volume":"5","author":"Sarntivijai","year":"2014","journal-title":"J. Biomed. Semantics"},{"key":"2019062104100219800_ref51","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/bioinformatics\/btq099","article-title":"Modeling sample variables with an Experimental Factor Ontology","volume":"26","author":"Malone","year":"2010","journal-title":"Bioinformatics"},{"key":"2019062104100219800_ref52","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref53","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2019062104100219800_ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-018-2211-5","article-title":"FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining","volume":"19","author":"Bachman","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2019062104100219800_ref55","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/JAD-170440","article-title":"Comorbidity analysis between Alzheimer\u2019s disease and type 2 diabetes mellitus (T2DM) based on shared pathways and the role of T2DM drugs","volume":"60","author":"Karki","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"2019062104100219800_ref56","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1471-2105-14-340","article-title":"Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data","volume":"14","author":"Catlett","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"2019062104100219800_ref57","doi-asserted-by":"crossref","first-page":"954","DOI":"10.15252\/msb.20177651","article-title":"From word models to executable models of signaling networks using automated assembly","volume":"13","author":"Gyori","year":"2017","journal-title":"Mol. Syst. Biol."},{"key":"2019062104100219800_ref58","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/582765","article-title":"Exploring biomolecular literature with EVEX: connecting genes through events, homology, and indirect associations","volume":"2012","author":"Van Landeghem","year":"2012","journal-title":"Adv. Bioinformatics"},{"key":"2019062104100219800_ref59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3115\/v1\/P15-4022","volume-title":"Proceedings of ACL-IJCNLP 2015 System Demonstrations","author":"Valenzuela-Esc\u00e1rcega","year":"2015"},{"key":"2019062104100219800_ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bay098","article-title":"Large-scale automated machine reading discovers new cancer-driving mechanisms","volume":"2018","author":"Valenzuela-Esc\u00e1rcega","year":"2018","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref61","first-page":"77","volume-title":"Natural Language Processing and Knowledge Representation","author":"McDonald","year":"2000"},{"key":"2019062104100219800_ref62","doi-asserted-by":"crossref","first-page":"bav057","DOI":"10.1093\/database\/bav057","article-title":"Construction of biological networks from unstructured information based on a semi-automated curation workflow","volume":"2015","author":"Szostak","year":"2015","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref63","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw067","article-title":"BioCreative V track 4: a shared task for the extraction of causal network information using the Biological Expression Language","volume":"2016","author":"Rinaldi","year":"2016","journal-title":"Database (Oxford)"},{"key":"2019062104100219800_ref64","first-page":"7310","article-title":"Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells","volume":"63","author":"Lovat","year":"2003","journal-title":"Cancer Res."},{"key":"2019062104100219800_ref65","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-07-6858","article-title":"BCR\/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations","volume":"68","author":"Stoklosa","year":"2008","journal-title":"Cancer Res."},{"key":"2019062104100219800_ref66","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2016.01.002","article-title":"Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages","volume":"1861","author":"Fournier","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2019062104100219800_ref67","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1186\/1471-2407-14-921","article-title":"Cross-talk between alpha 1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation","volume":"14","author":"Morelli","year":"2014","journal-title":"BMC Cancer"},{"key":"2019062104100219800_ref68","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.mcn.2005.07.015","article-title":"LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2","volume":"30","author":"Young","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"2019062104100219800_ref69","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/ijc.24072","article-title":"HINT1 inhibits \u03b2-catenin\/TCF4, USF2 and NF\u03baB activity in human hepatoma cells","volume":"124","author":"Wang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"2019062104100219800_ref70","doi-asserted-by":"crossref","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","article-title":"WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research","volume":"46","author":"Slenter","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baz068\/28850182\/baz068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T21:39:35Z","timestamp":1568929175000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baz068\/5521414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":70,"URL":"https:\/\/doi.org\/10.1093\/database\/baz068","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/536409","asserted-by":"object"}]},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019]]},"published":{"date-parts":[[2019,1,1]]},"article-number":"baz068"}}