{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:48:24Z","timestamp":1772322504852,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007059","name":"Palack\u00fd University Olomouc","doi-asserted-by":"publisher","award":["IGA_PrF_2019_031"],"award-info":[{"award-number":["IGA_PrF_2019_031"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERDF\/ESF Project \u201cNanotechnologies for Future\u201d","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000754"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000754"]}]},{"name":"ELIXIR CZ Research Infrastructure Project","award":["LM2015047"],"award-info":[{"award-number":["LM2015047"]}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["17-21122S"],"award-info":[{"award-number":["17-21122S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biological membranes act as barriers or reservoirs for many compounds within the human body. As such, they play an important role in pharmacokinetics and pharmacodynamics of drugs and other molecular species. Until now, most membrane\/drug interactions have been inferred from simple partitioning between octanol and water phases. However, the observed variability in membrane composition and among compounds themselves stretches beyond such simplification as there are multiple drug\u2013membrane interactions. Numerous experimental and theoretical approaches are used to determine the molecule\u2013membrane interactions with variable accuracy, but there is no open resource for their critical comparison. For this reason, we have built Molecules on Membranes Database (MolMeDB), which gathers data about over 3600 compound\u2013membrane interactions including partitioning, penetration and positioning. The data have been collected from scientific articles published in peer-reviewed journals and complemented by in-house calculations from high-throughput COSMOmic approach to set up a baseline for further comparison. The data in MolMeDB are fully searchable and browsable by means of name, SMILES, membrane, method or dataset and we offer the collected data openly for further reuse and we are open to further additions. MolMeDB can be a powerful tool that could help researchers better understand the role of membranes and to compare individual approaches used for the study of molecule\/membrane interactions.<\/jats:p>","DOI":"10.1093\/database\/baz078","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T07:08:33Z","timestamp":1558940913000},"source":"Crossref","is-referenced-by-count":18,"title":["MolMeDB: Molecules on Membranes Database"],"prefix":"10.1093","volume":"2019","author":[{"given":"Jakub","family":"Jura\u010dka","sequence":"first","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc, T\u0159. 17, listopadu 12, 771 46 Olomouc, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-2978","authenticated-orcid":false,"given":"Martin","family":"\u0160rejber","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc, T\u0159. 17, listopadu 12, 771 46 Olomouc, Czech Republic"}]},{"given":"Michaela","family":"Mel\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc, T\u0159. 17, listopadu 12, 771 46 Olomouc, Czech Republic"}]},{"given":"V\u00e1clav","family":"Bazgier","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc, T\u0159. 17, listopadu 12, 771 46 Olomouc, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-2589","authenticated-orcid":false,"given":"Karel","family":"Berka","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc, T\u0159. 17, listopadu 12, 771 46 Olomouc, Czech Republic"}]}],"member":"286","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"2019062722022953000_ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm2934","article-title":"Lipidomics: coming to grips with lipid diversity","volume":"11","author":"Shevchenko","year":"2010","journal-title":"Nat. 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