{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:28:55Z","timestamp":1774070935957,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":297,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009559","name":"Universidad Nacional de Quilmes","doi-asserted-by":"publisher","award":["PUNQ 1402\/15"],"award-info":[{"award-number":["PUNQ 1402\/15"]}],"id":[{"id":"10.13039\/501100009559","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Promociientca y Tecnola","award":["PICT-2014 3430"],"award-info":[{"award-number":["PICT-2014 3430"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure\u2013function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic promiscuity. ProtMiscuity contains information about canonical and promiscuous activities comprising 88 different reactions in 57 proteins from 40 different organisms. It can be searched or browsed by protein names, organisms and descriptions of canonical and promiscuous reactions. Entries provide information on reaction substrates, products and kinetic parameters, mapping of active sites to sequence and structure and links to external resources with biological and functional annotations. ProtMiscuity could assist in studying the underlying mechanisms of promiscuous reactions by offering a unique and curated collection of experimentally derived data that is otherwise hard to find, retrieve and validate from literature.<\/jats:p>","DOI":"10.1093\/database\/baz103","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T15:30:41Z","timestamp":1569339041000},"source":"Crossref","is-referenced-by-count":11,"title":["ProtMiscuity: a database of promiscuous proteins"],"prefix":"10.1093","volume":"2019","author":[{"given":"Ana Julia","family":"Velez Rueda","sequence":"first","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Roque S\u00e1enz Pe\u00f1a 352, Bernal B1876BXD Buenos Aires, Argentina"}]},{"given":"Nicolas","family":"Palopoli","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Roque S\u00e1enz Pe\u00f1a 352, Bernal B1876BXD Buenos Aires, Argentina"}]},{"given":"Mat\u00edas","family":"Zacar\u00edas","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Roque S\u00e1enz Pe\u00f1a 352, Bernal B1876BXD Buenos Aires, Argentina"}]},{"given":"Leandro Mat\u00edas","family":"Sommese","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Roque S\u00e1enz Pe\u00f1a 352, Bernal B1876BXD Buenos Aires, Argentina"}]},{"given":"Gustavo","family":"Parisi","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Roque S\u00e1enz Pe\u00f1a 352, Bernal B1876BXD Buenos Aires, Argentina"}]}],"member":"286","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"2019102420291427600_ref1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tibs.2014.12.004","article-title":"An evolutionary biochemist\u2019s perspective on promiscuity","volume":"40","author":"Copley","year":"2015","journal-title":"Trends Biochem. 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